铁硫蛋白是含铁的蛋白质，也是细胞色素类蛋白。是在蛋白质的中央含有四个原子，其中两个是铁，另两个是硫，称为【2Fe-2S】,或在蛋白质的中央含有八个原子，其中四个是铁，另四个是硫，称为【4Fe-4S】,并且通过硫与蛋白质的半胱氨酸残基相连。

2024年12月4日 · Nature Communications - De novo [2Fe-2S] cluster synthesis by the mitochondrial ISC complex requires electrons from ferredoxin-2 (FDX2). The authors map FDX2 binding to the core ISC complex,...

2Fe–2S clusters. The simplest polymetallic system, the [Fe 2 S 2] cluster, is constituted by two iron ions bridged by two sulfide ions and coordinated by four cysteinyl ligands (in Fe 2 S 2 ferredoxins) or by two cysteines and two histidines (in Rieske proteins).

2014年4月14日 · Monothiol glutaredoxins play a crucial role in iron–sulfur (Fe/S) protein biogenesis. Essentially all of them can coordinate a [2Fe-2S] cluster and have been proposed to mediate the transfer of [2Fe-2S] clusters from scaffold proteins to target apo proteins, possibly by acting as cluster transfer proteins.

2025年1月28日 · Iron–sulfur (Fe–S) clusters are among the oldest cofactors and exist in a variety of forms, the most common being rhombic [2Fe–2S] and cubane [4Fe–4S] clusters 2. These clusters are present in a...

2024年4月16日 · Collectively, our study defines crucial mechanistic stages of physiological [2Fe-2S] cluster assembly and clarifies frataxin’s molecular role in this fundamental process.

This feature article reviews the synthesis, structural comparison, and physical properties of [2Fe–2S] model compounds, which serve as vital tools for understanding the structure and function of Fe–S clusters in biological systems.

2013年5月17日 · Escherichia coli [2Fe-2S]-ferredoxin (Fdx) is encoded by the isc operon along with other proteins involved in the ‘house-keeping’ mechanism of iron–sulfur cluster biogenesis.

2013年6月5日 · Escherichia coli [2Fe-2S]-ferredoxin (Fdx) is encoded by the isc operon along with other proteins involved in the 'house-keeping' mechanism of iron-sulfur cluster biogenesis. Although it has been proposed that Fdx supplies electrons to reduce sulfane sulfur (S(0)) produced by the cysteine desulfuras …

2025年1月21日 · 本专题文章回顾了 [2Fe-2S] 模型化合物的合成、结构比较和物理性质，它们是了解生物系统中 Fe-S 团簇结构和功能的重要工具。 我们探索了构建 [2Fe–2S] 核心的各种合成方法，并深入了解了它们的仿生相关性。