使用 miR-378-3p 的稳定敲低生成了模拟 MDS 的异常骨髓成熟模型。 该模型表现出转录谱，表明异常的成熟和功能、免疫表型和形态学发育不良以及MDS特征的异常生长。

miR-378 has been proven to inhibit cell growth, migration and invasion in different types of cancers. In this study, we found that miR-378 was commonly downregulated in the bone marrow cells obtained from myelodysplastic syndrome (MDS) patients.

2021年11月1日 · Myelodisplastic syndrome (MDS) is a group of clonal hematopoetic stem cell (HSC) disorders, predominantly of the elderly population, that carry an increased risk of transformation to an acute myeloid leukemia. 1 MDS is characterized by cytopenias with dysplasia in one or more lineages of the bone marrow. 1, 2 MDS has been associated with a ...

Hypomethylation level of MIR‐378 was significantly higher in myelodysplastic syndrome (MDS) patients than that in controls (p = .034). MIR‐378‐hypomethylated patients had significantly shorter overall survival than those without MIR‐378 hypomethylation (p = .036).

Overexpression of miR-378 can suppress MDS/AML cell growth by promoting apoptosis and blocking G1/S-phase transition, at least, partly via negatively regulating Bcl-w and CDC40 expression. However, because each miRNA can regulate multiple target genes and the miRNA-regulated signaling pathways are complex, the specific mechanisms of miR-378 in ...

A model of aberrant myeloid maturation that mimics MDSs that is seen in MDSs has been created using a stable knockdown of miR-378-3p. This model exhibited a transcriptional profile that indicates aberrant maturation and function, immunophenotypic and morphologic dysplasia, and aberrant growth and function that characterizes MDSs.

Results: Unmethylated level of MIR-378 5'-flanking region was significantly higher in MDS patients than that in controls (p = .034). Hypomethylated MIR-378 was identified in 20 of 95 (21%) cases with MDS. Male patients appeared to be more frequent to harbor MIR-378 hypomethylation compared to female patients (15/55, 27.3% vs. 4/40, 10.0%, p = .04).

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Download scientific diagram | Relative Levels of MIR‐378 unmethylation in MDS and control. The cutoff value of the mean plus 1 SD (0.252) in normal controls was displayed with the dotted line.

Results indicated that overexpression of miR-378 in SKM-1 cells interfered with proliferation via inducing apoptosis and G0/G1-phase cell cycle arrest, and suppressive effect of miR-378 on MDS/AML cells may be mediated partly through Bcl-w and CDC40.