6 天之前 · ILF2 (Interleukin Enhancer Binding Factor 2) is a Protein Coding gene. Diseases associated with ILF2 include Japanese Encephalitis and Encephalitis. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Innate Immune System.

编码的 45 kDa 蛋白 (NF45、ILF2) 与 90 kDa 白介素增强子结合因子 3 (NF90、ILF3) 形成复合物，该复合物已被证明会影响核 mRNA 向细胞质的重新分布，从而修复 DNA 断裂通过非同源末端连接，并负向调节 MicroRNA 加工途径。 NF45 或 NF90 蛋白的敲低可能通过抑制 mRNA 稳定来延迟细胞生长。 可变剪接导致多个转录本变体。 在 3 号和 14 号染色体上发现了相关的假基因。 [RefSeq 提供，2014 年 12 月]

2024年12月13日 · Recent studies have shown that ILF2 expression is significantly upregulated in esophageal cancer, lung cancer, gastric cancer, and other malignant tumors, which can promote tumor development and tumor cell proliferation, affect the cell cycle, and induce epithelial-mesenchymal transition.

2024年12月12日 · Interleukin enhancer binding factor 2 (ILF2), formerly called nuclear factor 45 (NF45), is widely expressed in normal human tissues. ILF2 often binds to interleukin enhancer binding factor 3 (ILF3) and regulates gene expression in several ways, participating in multiple DNA and RNA metabolism pathways.

2016年8月22日 · Interleukin enhancer binding factor 2 (ILF2), a transcription factor, regulates cell growth by inhibiting the stabilization of mRNA. Currently, its role has gained recognition as a factor in the tumorigenic process. However, until now, little has been known about the detailed role ILF2 plays in hepatocellular carcinoma (HCC).

Background: 1q21.3 amplification, which is frequently observed in metastatic melanoma, is associated with cancer progression. Interleukin enhancer-binding factor 2 (ILF2) is located in the 1q21.3 amplified region, but its functional role or contribution to tumour aggressiveness in cutaneous melanoma is unknown.

2025年1月5日 · In addition, your package will include a detailed data report in both TSV and JSONL formats. The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase.

Interleukin enhancer binding factor 2 (ILF2) participates in several aspects of DNA and RNA metabolism and regulates gene expression at multiple levels; however, its role in breast cancer remains undefined. The variant statuses of ILF2 in human breast cancer were evaluated using the COSMIC database.

ILF2 encodes NF45, the regulatory subunit of NF90/NF110 complexes that are involved in mitotic control (Guan et al., 2008) and various aspects of RNA metabolism, including transcription, RNA transport, mRNA stability, and translation (Barber, 2009).

2018年6月2日 · In this study, by establishing and using a reconstructed NLRP3 inflammasome activation system, we reveal that the NLRP3 inflammasome activation, pro-caspase-1 cleavage, and pro-interleukin-1β (pro-IL-1β) activation are repressed by the …