
4E-BP1, a multifactor regulated multifunctional protein
Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway. Phosphorylation of 4E-BP1 causes its release from eIF4E to allow cap-depen …
Phospho-4E-BP1 (Thr37/46) (236B4) Rabbit mAb #2855
Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation (1).
EIF4EBP1 - Wikipedia
Eukaryotic translation initiation factor 4E-binding protein 1 (also known as 4E-BP1) is a protein that in humans is encoded by the EIF4EBP1 gene. [5] inhibits cap-dependent translation by binding to translation initiation factor eIF4E. Phosphorylation of 4E-BP1 results in its release from eIF4E, thereby allows cap-dependent translation to ...
MCE | mTOR 通路是如何调控自噬的 - 知乎 - 知乎专栏
mtorc1 活化后,通过磷酸化下游效应因子 s6k 和 4e-bp 促进合成代谢过程,例如蛋白质、脂质和核苷酸合成,同时,通过 ulk1 抑制分解代谢程序,从而导致自噬抑制。
茁彩生物ㅣ高度保守的小分子蛋白——4E-BP1 - 百度
2023年6月7日 · 真核翻译起始因子4E结合蛋白1(eIF4E-bind-ing protein 1,4E-BP1)是一种高度保守的小分子蛋白,在蛋白翻译起始途径选择中发挥重要的功能。 4E-BP1通过与脚手架蛋白elF4G竞争性结合转录起始因elF4E,抑制elF4E的功能及帽依赖性蛋白质翻译起始。
4E-BP1, a multifactor regulated multifunctional protein - PMC
Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway. Phosphorylation of 4E-BP1 causes its release from eIF4E to allow cap-dependent translation to proceed.
Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a
2016年2月1日 · Here we describe the molecular and cellular functions of 4E-BP1 and highlight the distinct roles of 4E-BP1 in cancer depending on the microenvironmental context of the tumor. Cancer cells...
4E-BPs require non-canonical 4E-binding motifs and a lateral
2014年9月2日 · Our data reveal a hitherto unrecognized role for the NC4E-BMs and the lateral surface of eIF4E in 4E-BP-mediated translational repression, and suggest that bipartite 4E-BP mimics might...
真核起始因子4E结合蛋白1(4E-BP1)的磷酸化动力学与其与真核起始因子4E…
雷帕霉素(mtor)的哺乳动物靶标凭借其调节蛋白质翻译的能力来控制细胞的生长和增殖。真核起始因子4e(eif4e)结合蛋白1(4e-bp1)-一个关键的mtor底物,结合并螯合eif4e来阻止翻译起始,据认为这是通过mtor进行4e-bp1磷酸化而克服的。
「珍藏版」Cell综述|细说mTOR底物磷酸化 - 百家号
这释放了4E-BP,允许eIF4E结合eIF4G并启动翻译。最近的一项研究阐明了mTORC1如何识别4E-BP并以分层方式对其进行磷酸化。mTORC1通过RAPTOR结合4E-BP的TOS和RAIP motif(Arg-Ala-Ile-Pro,仅在4E-BP中发现)。RAPTOR对这些motif的结合使4E-BP的磷酸化位点朝向mTORC1活性位点。