2019年10月30日 · The Defense Information Systems Agency (DISA) has begun the implementation phase for the Fourth Estate Network Optimization Initiative and will now begin building the network for 14 defense agencies. The endeavor will standardize equipment, enhance cybersecurity, improve interoperability and save significant money, DISA officials say.

2020年12月1日 · The 4ENO initiative aims to bring 22 of the support agencies’ networks into one consolidated service and support operation run by DISA. Agencies in the Fourth Estate, which includes operations like the Defense Logistic Agency, currently operate their own IT systems and help desks, creating redundancies and security weaknesses, officials have ...

2022年2月28日 · Under the indefinite-delivery, indefinite-quantity Defense Enclave Services contract, Leidos will lead what DISA calls the Fourth Estate Network Optimization (4ENO) initiative — an effort to modernize and move the Department of Defense ‘s 22 Fourth Estate agencies and field activities to a single platform.

Join us as Mr. Drew Jaehnig, chief of the 4th Estate Network Optimization effort, details the collaborative alignment of common use IT across the DOD.With a ...

4ENO: Crystal structure of oxidized human nm23-H1

The 4ENO program is a bold, aggressive reform designed to implement structural change by creating an IT enterprise that is more modern, more secure, and more capable for 13 Defense Agencies and...

Here, the crystal structure of oxidized Nm23-H1 is presented. It reveals the formation of an intramolecular disulfide bond between Cys4 and Cys145 that triggers a large conformational change that destabilizes the hexameric state.

2019年10月31日 · 据美国陆海空通信和电子协会（AFCEA）网站10月30日消息，美国国防信息系统局（DISA）已进入“第四等级网络优化（the Fourth Estate Network Optimization，4ENO）计划”实施阶段，将开始为14个国防机构搭建网络。

Function [ NDKA_HUMAN] Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor ...

Biological Unit for 4ENO: hexameric; determined by author and by software (PISA) Molecular Graphic ?