2024年5月9日 · In this study, novel self-assembled ultrasmall Fe3O4 nanoclusters were developed for tumor-targeted dual-mode T1/T2-weighted magnetic resonance imaging (MRI) guided synergetic chemodynamic...

第三部分研究中我们通过小鼠4t1乳腺癌移植瘤模型，以瘤体积和瘤重的变化来评价dox-nps体内的抑制肿瘤生长的效果，以肺部表面节结数及转移灶面积为指标来评价其抗转移效果。

2024年10月19日 · The in vitro studies on the cell viability and cytotoxicity of Fe3O4/CeO2 nanocomposites demonstrated superior effectiveness of the green-synthesized sample (AFC) compared to the chemically produced variant (FC) against 4T1 cells. Treatment with AFC significantly reduced tumor size in 4T1-injected BALB/c mice compared to untreated control.

2024年12月19日 · Siglec-G siRNA blocks the CD24/Siglec-G mediated “don’t eat me” phagocytosis inhibition pathway, activating macrophages, enhancing their phagocytic function, and improving antigen presentation, subsequently triggering anti-tumor immune responses. Fe3O4 repolarizes M2-TAMs to the anti-tumor M1 phenotype.

2023年9月1日 · Fe 3 O 4 -SWCNT@M1 can migrate to tumor cells and release NO, ROS and TNF-α. It can promote M2-like cells polarization and inhibit tumor progression. Macrophage-based tumor immunotherapy can effectively kill tumor cells in a direct manner when tumor specific antigens are idle or unknown.

纳米粒子由Fe3O4/Au为核心，包被聚多巴胺，结合叶酸和负载抗癌药物（多柔比星）组成。 所提出的多功能纳米粒子在治疗应用中显示出许多优点，例如良好的生物相容性和生物缀合能力。 纳米粒子的聚多巴胺涂层与近红外激光相同的强度与Fe3O4/Au纳米粒子相比，显示出更高的光热效应，因此能更有效的杀死癌症细胞。 此外，叶酸偶联显示可通过叶酸受体增强癌细胞摄取效率，从而提高化疗效率。 通过体外癌细胞治疗测试，所提出的多功能NPs表现出先进的光热和化学治疗 …

本研究采用化学共沉淀法制备了Fe3O4纳米颗粒,并借助酰胺反应将核酸适配体 (Apt23)偶联在颗粒表面,形成了钙网蛋白受体靶向的氧化铁纳米颗粒 (Fe3O4@Apt),并进一步研究了Fe3O4@Apt纳米颗粒对4T1乳腺癌细胞的热疗效应。

2018年8月17日 · The FeNP/CpG particle delivery system, with enhanced cell uptake of CpG in bone marrow-derived dendritic cells (BMDCs) in vitro and through intratumoral injection, showed significant antitumor ability by stimulating better humoral and cellular immune responses in C26 colon cancer and 4T1 breast cancer xenograft models in vivo over those of free ...

2021年3月12日 · The released Ce6 can increase the generation and accumulation of ROS under laser irradiation to offer photodynamic therapy, which can boost ferroptosis in 4T1 cells. Moreover, magnetic monodisperse Fe3O4 loading provides excellent T2-weighted magnetic resonance imaging (MRI) properties.

2024年5月9日 · In this study, novel self-assembled ultrasmall Fe3O4 nanoclusters were developed for tumor-targeted dual-mode T1/T2-weighted magnetic resonance imaging (MRI) guided synergetic chemodynamic...