PEG-cRGD表面修饰不仅提高了其稳定性，而且增强了其靶向肿瘤的能力。在内源性高水平H2O2存在的4T1细胞中，被包裹的MnCO分解为Mn2+和CO，导致caspase-3激活。活化的caspase-3裂解全长GSDME诱导细胞凋亡，最终释放出大量的DAMPs。

2023年9月1日 · Results not only confirmed ROS generation ability of CuS@Alg NPs within cells, but also show the anticancer ability of them. By CDT, the created smart nanoscale system showed remarkable effectiveness for breast cancer suppression.

2021年12月9日 · We found that NPS treatment enhanced the immunogenicity of 4T1-luc mouse mammary tumor, resulted in a potent in situ vaccination protection and induced long-term T cell immunity. ROS production...

2019年4月12日 · To this aim, 4T1 tumor-bearing mice were intravenously injected with different formulations for 8 h followed by the intraperitoneal administration of the ROS probe, Cellular Reactive Oxygen ...

在纳米光疗中以低剂量（6 gy），ros引起的增敏rt的原位4t1乳腺癌小鼠中观察到完全根除原发肿瘤和强效抑制肺转移，83％小鼠的生存率可达到60天。 原文链接：

2025年3月21日 · The fluorescent probe DCFH-DA was used to determine the level of ROS production in cells after material treatment. 4T1 cells were inoculated into 24-well plates at a density of 1 × 10 5 cells/mL ...

2024年10月1日 · Based on these two strategies for ROS generation, we have developed a robust ROS generation nanosystem loaded with AA (denoted as CTFAP) for mutually reinforcing ferroptosis and cancer immunotherapy. AS shown in Scheme 1, pH-sensitive CaO 2 nanoparties we synthesized and used as the template for preparing AA-loaded CaO 2 @TCPP-Fe (CTFA ...

2024年9月18日 · We designed a hybrid nanoparticle–based ISV, which accomplished superior cancer immunotherapy via simultaneously scavenging reactive oxygen species (ROS) and activating the stimulator of interferon genes (STING) pathway in DCs.

2023年6月15日 · 体外和体内实验结果均验证了该策略能在肿瘤细胞内特异性产生ROS风暴，并实现了小鼠乳腺癌的高效铁死亡治疗。该研究成果以“Tumor-Generated Reactive Oxygen Species Storm for High-Performance Ferroptosis Therapy”为题发表于ACS Nano期刊（影响因子18.027，中科院小类一区）。 图 1.

2023年7月1日 · To explore the cascade self-amplifying prodrug activation of PPHI@B/L, the intracellular ROS generation was examined in 4T1 cells. Dichlorofluorescein diacetate (DCF-DA) was employed as a ROS indicator, and the green fluorescence was detected by confocal laser scanning microscopy (CLSM) and flow cytometry (FACS).