2024年8月1日 · XBP1s facilitated RNA m6A methylation by activating transcription of METTL3 and METTL14. m6A methylation mediated ER-phagy by stabilizing CALCOCO1 and p62 mRNA. PTX could trigger the ER stress and ER-phagy formation. STM2457 and SAH produced a synergetic effect with PTX to inhibit breast cancer growth.

2024年6月18日 · We found that XBP1 splicing events were naturally increased in long-term paclitaxel-treated MDA-MB-231-PTXR and 4T1-PTXR (Fig. 1H), which may promote cancer cell survival and adaptation to stress. Previous studies have shown that overexpression of XBP1-s resistance is associated with poor clinical outcomes in endocrine therapy for breast cancer.

2024年8月30日 · Here, we report a strategy to create synthetic transcriptional repressors (STRs) that mimic the basic leucine zipper domain of XBP1 and recognize UPRE and HRE motifs. A lead molecule, STR22,...

2024年4月18日 · In this study, we demonstrate cross talk between the IRE1 and PERK branches of the UPR, wherein IRE1 via XBP1s signaling helps to sustain PERK expression during prolonged ER stress. Our findings...

2022年3月8日 · Notably, one cluster on the 4T1 (cluster 3) displayed a gene signature typical of plasma B cells (high expression of Cd27, Cd38, Xbp1) [39, 40] that was not observed in the EMT6 counterpart ...

接下来，研究团队建立4t1乳腺癌模型，验证纳米乳剂在体内的作用。 实验数据显示，α-TK有效降低了XBP1的表达，使M2细胞重极化为M1表型，延缓了肿瘤的生长。

2018年10月10日 · The RNase domain cleaves a 26-nucleotide intron within unspliced X Box binding Protein 1 (XBP1) or XBP1u mRNA. The resulting fragments are ligated by RNA 2′,3′-cyclic phosphate and 5′-OH ligase (RtcB) to generate spliced XBP1 or XBP1s mRNA, encoding the transcription factor XBP1s which promotes transcription of ER chaperones and ...

2023年12月9日 · To create a model of antiestrogen responsive BC with spontaneous metastasis, we developed a mouse model of 4T1.2 triple-negative (TN) breast cancer with virally transduced ER expression that metastasizes spontaneously without exogenous estrogen stimulation and is responsive to antiestrogen drugs.

2012年2月1日 · XBP1s/DC potentiates NeuEDhsp70 genetic vaccine to elicit therapeutic CD8-dependent antitumor immunity against established breast tumor 4T1.2-Neu and attenuate tumor-associated Treg suppressive function

2022年5月11日 · Its targets are X-box protein 1 (XBP1) mRNA, from which IRE1α removes a short intron producing XBP1 spliced (4), as well as other mRNAs (and miRNAs) whose cleavage triggers their degradation in a process termed regulated IRE1α-dependent decay (RIDD; 5).