A long-acting GH receptor antagonist through fusion to GH …
2016年10月12日 · GH receptor (GHR) antagonist therapy is more effective but requires frequent high-dose injections. We have developed an alternative technology for generating a long acting potent GHR antagonist...
Model for growth hormone receptor activation based on …
2005年8月21日 · Growth hormone is believed to activate the growth hormone receptor (GHR) by dimerizing two identical receptor subunits, leading to activation of JAK2 kinase associated with the cytoplasmic...
重组人生长激素(Novo Nordisk A/S)(Somatropin(Novo Nordisk A/S)) - 药物靶点：GHR…
Despite having normal growth hormone (GH) secretion, individuals with Turner syndrome (TS) have short stature. Treatment with recombinant human GH is recommended for TS girls with short stature. This work aimed to evaluate the effectiveness and safety of Norditropin (somatropin, Novo Nordisk) with up to 10 years of follow-up in children with TS.
Growth hormone receptor inhibition decreases the growth and …
2014年10月10日 · Growth hormone receptor (GHR), a member of the cytokine receptor superfamily, has been shown to regulate multiple cellular pathways including KRAS and insulin-like...
The growth hormone receptor interacts with transcriptional …
2023年4月12日 · HMGN1 was localised exclusively in the nucleus of RL95-2 cells, and was found to be associated with the GHR following 5 min of GH treatment, as demonstrated by co-immunoprecipitation using the combination of anti-GHR IC and anti-GHR EC antibodies as …
生长激素受体GHR靶点蛋白作用机理 - 华美生物
2023年9月15日 · 生长激素受体（growth hormone receptor, GHR）跨膜蛋白质，广泛存在于人体内各种细胞中。 它主要负责介导生长激素（GH）在目标细胞上的生物学效应，调节细胞生长、增殖和分化等生理过程。 GHR 可以通过配体结合和自身酪氨酸激酶活性的激活，促进细胞内的多种信号通路的启动，包括 JAK-STAT 、PI3K/Akt 和 Ras/MAPK 等信号通路，这些信号通路的激活将刺激多种信号转导与反应，并影响基因表达和细胞代谢。 当生长激素（GH）进入细胞后，会 …
Regulation of human growth hormone receptor expression by …
GHR deficiency is associated with growth and metabolic disorders whereas increased GHR expression has been reported in certain cancers, suggesting that the GHR gene requires tight controls. Several regulatory mechanisms have been found within its 5'-untranslated region (UTR) promoter and coding regions.
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