5F-APINACA (also known as A-5F-PINACA, [3] 5F-AKB-48 or 5F-AKB48) is an indazole -based synthetic cannabinoid that has been sold online as a designer drug. [4][5] Structurally it closely resembles cannabinoid compounds from patent WO 2003/035005 but with a 5-fluoropentyl chain on the indazole 1-position, and 5F-APINACA falls within the claims of...

5F-AKB48 (also known as 5F-APINACA and AKB-48F) is a synthetic cannabinoid substance of the indazolecarboxamide class. It acts as a potent agonist for the CB1 and CB2 cannabinoid receptors[1]

AKB48 N- (5-Fluoropentyl) analog is a member of indazoles and an aromatic amide. N- (adamantan-1-yl)-1- (5-fluoropentyl)-1H-indazole-3-carboxamide is a DEA Schedule I controlled substance.

2013年7月4日 · 5F-AKB48 is a novel synthetic cannabinoid and N- (5-fluoropentyl) analog of AKB48. 5F-AKB48 has a strong binding affinity for the peripheral CB2 cannabinoid receptors, while possessing a greatly reduce affinity for the central CB1 cannabinoid receptors.

5-fluoro AKB48 differs structurally from AKB48 by having fluorine at the terminal carbon of the pentyl chain. While the physiological properties of this compound are not known, quinolones with adamantyl- carboxamide moieties display high affinity for the peripheral CB 2 receptor but greatly reduced affinity for the central CB 1 receptor. 1 This ...

2024年8月4日 · 5F-AKB48, also known as 5F-APINACA, is a synthetic cannabinoid belonging to the indazole-3-carboxamide family. It is a derivative of AKB48 (APINACA), where the pentyl chain is replaced by a fluoropentyl chain.

本研究旨在研究来自不同器官和性别的人微粒体部分以及重组人细胞色素 P450s (P450s) 对 5F-AKB48 的体外氧化代谢。 质谱数据暂时为连续代谢中存在单羟基、二羟基和三羟基代谢物提供了证据。

5F-APINACA (5F-AKB-48) is an analogue of APINACA (AKB-48) fluorinated on the terminal carbon of the pentyl side chain. It belongs to the category of synthetic cannabinoid receptor agonists (SCRAs), which have affinity for CB 1 and CB 2 receptors with activation of the former

To measure intrinsic activity of Δ 9-THC (open circles), 5F-AKB48 (open squares) or 40H-5F-AKB48 (open triangles), increasing concentrations (0.1 nM – 10 μM) of each compound to increase [35 S]GTPγS binding via CB1 receptor activation in …

The present studies were designed to investigate the in vitro oxidative metabolism of 5F-AKB48 by human microsomal fractions from different organs and sexes as well as recombinant human cytochrome P450s (P450s).