5F-PB-22 (5F-QUPIC or quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate) is a designer drug which acts as a cannabinoid agonist. [2] The structure of 5F-PB-22 appears to have been designed with an understanding of structure–activity relationships within the indole class of …

5-fluoro PB-22 (Item No. 14095) is an analytical reference material categorized as a synthetic cannabinoid. 1,2 5-fluoro PB-22 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

2017年10月1日 · In this study, we characterised 5F-PB-22 and its three fluoropentyl isomers using GC–MS, solid deposition GC–IRD and 1 H and 13 C NMR spectroscopy. The results showed that the isomers could be differentiated by these techniques and 5F-PB-22 was positively identified in a seized sample.

Substances in the DEA Schedule I have no currently accepted medical use in the United States, a lack of accepted safety for use under medical supervision, and a high potential for abuse. It is a Hallucinogenic substances substance. See also: PB-22 (annotation moved to). Computed by PubChem 2.2 (PubChem release 2021.10.14)

2014年2月12日 · PB-22 (1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid) and 5F-PB-22 (1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid) are new synthetic cannabinoids with a quinoline substructure and the first marketed substances with an ester bond linkage.

2017年4月28日 · Metabolism of four synthetic cannabinoids, 5F-PB-22, XLR-11 and their defluorinated analogues PB-22 and UR-144 respectively, were investigated using the fungus C. elegans. The phase I and II metabolites were identified based on LC-QTOF analysis, and their metabolic pathways were proposed.

Structurally, PB-22 and 5F-PB-22 are similar to JWH-018 and AM2201 respectively, two of the most common first and second generation abused synthetic cannabinoids. Both contain an N-alkylindole moiety, however the napthylacyl group has been replaced by a quinolinyl ester. Biological and toxicological data has not been reported for these compounds.

5F-PB-22 binds to and activates CB1 receptors, and it induces a number of biological responses that are also triggered by SCRAs and THC. It produces some cannabimimetic effects in laboratory animals, including the suppression of locomotor activity and reduction of core temperature.

Quinolin-8-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate (5-Fluoro-PB-22 or 5F-PB-22; QUPIC N-(5-fluoropentyl) analog), is a synthetic cannabinoid which mimics the effects of cannabis. Several countries have reported numerous detections of this compound and its …

Results: The predominant metabolic pathway for PB-22 and 5F-PB-22 was ester hydrolysis yielding a wide variety of (5-fluoro)pentylindole-3-carboxylic acid metabolites. Twenty metabolites for PB-22 and 22 metabolites for 5F-PB-22 were identified, with the majority generated by oxidation with or without glucuronidation.