2015年1月18日 · 5xFAD mice develop motor impairments, beginning at about 9 months of age (O’Leary et al., 2018; O’Leary et al., 2018). On the Rotarod, transgenic mice fall off more quickly than controls, and improve little across trials. 5xFAD mice also fall more quickly when tested on a balance beam, and in wire- and grid-suspension tests.

2025年1月30日 · 5xFAD mice performed similarly to non-transgenic animals in a contextual fear conditioning paradigm, a test of associative learning, administered at 4, 8, 12, and 18 months of age (Forner et al., 2021).

2019年1月18日 · Bace1 deletion also ameliorates deficits in long-term potentiation and cognition that are seen in 5xFAD mice. Unless stated otherwise, this description refers to comparisons between 5xFAD/BACE1 KO mice and 5xFAD mice homozygous for floxed Bace1 but without the Cre recombinase transgene (hereafter, “control 5xFAD”).

2020年11月27日 · Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci. 2006 Oct 4;26 (40):10129 …

McCool S, Smith JC, Sladek A, Fan S, Van Hook MJ. Retinal and thalamic alterations in the 5xFAD mouse model of Alzheimer's disease. PLoS One. 2025;20 (3):e0319397. Epub 2025 Mar 3 PubMed. Recommends Please login to recommend the paper. Make a Comment

This difference may reflect the lower number of microglia in the brains of 5xFAD; Trem2 H157Y/H157Y mice, as discussed below. The sTREM2/full-length-TREM2 ratio was higher in 5xFAD; Trem2 H157Y/H157Y mice, consistent with increased sTREM2 shedding in H157Y carriers. Levels of serum sTREM2 were higher in homozygous carriers of the H157Y mutation.

2023年9月11日 · The M28L mutation appeared to disrupt microglial interactions with amyloid plaques. The percent area occupied by Iba1- or CLEC7A-immunoreactive microglia within X34-positive plaques was lower in 5xFAD M28L than in 5xFAD mice. Percent colocalization of Iba1 and 6E10 immunoreactivity was also decreased in 5xFAD M28L mice, compared with 5xFAD …

2024年9月19日 · PubMed identified 1,122 studies using the 5xFAD mouse strain alone since 2018, while 2,034 studies used APP/PS1 mice and 548 used 3xTg. Still, Sasner expects more studies with MODEL-AD mice to come down the pike soon.

2017年6月9日 · Availability: 5xFAD mice are available through The Jackson Lab, Stock# 034840; Live. APOE4 Targeted Replacement mice are available through Taconic, Stock# 1549-F or 1549-M. The E4FAD, E3FAD, and E2FAD mouse models are crosses between the widely used 5xFAD mice (Tg6799 line) and the APOE4, APOE3, and APOE2 Targeted Replacement mice, …

2024年12月7日 · In addition, they ran spatial transcriptomics on 5xFAD mouse samples at various stages of amyloidosis to see how well the model tracked changes in AD (see workflow below). AD in Time and Space.