2012年3月16日 · No MOAB-2 immunoreactivity was observed in the brains of 5xFAD/BACE-/-mice although significant amounts of APP were detected with anti-APP antibodies as well as by 6E10. In both 5xFAD and 3xTg mouse tissue, MOAB-2 co-localized with cathepsin-D, a marker for acidic organelles, providing further evidence for specifically identifying intraneuronal ...

2021年1月15日 · We observed ThS-labeled insoluble protein aggregates that were not positive for anti-Aβ antibodies, 6E10 or 4G8, in the cortical and hippocampal regions of both male and female 5XFAD mice.

2021年10月15日 · Here we conducted a detailed phenotypic characterization of the 5xFAD model on a congenic C57BL/6 J strain background, across its lifespan – including a seldomly analyzed 18-month old time point...

2023年7月20日 · We found a strong correlation between Arl8b- and 6E10-stained structures in hippocampal tissues of all three ages (Fig. 5f), suggesting that the time-dependent formation of amyloid plaques determines the size of the adjacent Arl8b-positive lysosomal structures in …

Results The new mouse model, called 5xFAD TAU, shows accelerated cognitive impairment at 2 months of age, increased number of Aβ depositions at 4 months and neuritic plaques at 6 months of age.

2023年8月9日 · Our study showed that single systemic wild-type (WT) hematopoietic stem and progenitor cell (HSPC) transplantation rescued the AD phenotype in 5xFAD mice and that transplantation may prevent microglia activation.

2023年7月5日 · Here, we discovered carprofen, a non-steroidal anti-inflammatory drug, accelerates Aβ aggregating into fibrils and increases Aβ plaques when intraperitoneally injected to 5XFAD transgenic mouse...

2013年1月14日 · The 5XFAD mouse model of amyloid deposition expresses five familial AD (FAD) mutations that are additive in driving Aβ 42 overproduction. 5XFAD mice exhibit intraneuronal Aβ 42 accumulation at 1.5 months, amyloid deposition at 2 months, and memory deficits by 4 months of age.

2012年3月16日 · Results: MOAB-2 (mouse IgG2b) is a pan-specific, high-titer antibody to Aβ residues 1-4 as demonstrated by biochemical and immunohistochemical analyses (IHC), particularly compared to 6E10 (a commonly used commercial antibody to Aβ residues 3-8). MOAB-2 did not detect APP or APP-CTFs in cell culture media/lysates (HEK-APPSwe or …

2017年4月1日 · Chronic xamoterol reduces pathology and neuroinflammation in 5XFAD model of AD. Degeneration of noradrenergic neurons occurs at an early stage of Alzheimer's Disease (AD). The noradrenergic system regulates arousal and learning and memory, and has been implicated in regulating neuroinflammation.