RCSB PDB - 7BQV: Cereblon in complex with SALL4 and (S)-5 ...
Here, we report the structural bases for the SALL4-specific proteasomal degradation induced by 5-hydroxythalidomide, a primary thalidomide metabolite generated by the enzymatic activity of cytochrome P450 isozymes, through the interaction with cereblon (CRBN).
RCSB PDB - 7BQU: Cereblon in complex with SALL4 and (S) …
2020年8月26日 · Here, we report the structural bases for the SALL4-specific proteasomal degradation induced by 5-hydroxythalidomide, a primary thalidomide metabolite generated by the enzymatic activity of cytochrome P450 isozymes, through the interaction with cereblon (CRBN).
7BQV: Cereblon in complex with SALL4 and (S)-5 …
" MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42 (Database issue):D297-303.
Structural bases of IMiD selectivity that emerges by 5 ... - Nature
2020年9月14日 · Coordinates and structure factors are available in the PDB under accession numbers 7BQV for the SALL4–CRBN complex with (S)-5HT and 7BQU for the SALL4–CRBN complex with (S)-thalidomide. The ...
PDB 7bqv structure summary ‹ Protein Data Bank in Europe …
2020年8月26日 · 7bqv: Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide.
Experiment: 7BQV - RCSB PDB
7BQV. Cereblon in complex with SALL4 and (S)-5-hydroxythalidomide. X-RAY DIFFRACTION. Starting Model(s) Initial Refinement Model(s) Type Source Accession Code Details; experimental model: PDB: 7BQU : Crystallization. Crystalization Experiments; ID Method pH Temperature Details; 1: VAPOR DIFFUSION, SITTING DROP: 293: 22% PEG 4000, 0.1 M MES (pH ...
PDB ID : 7BQV Title : Cereblon in complex with SALL4 and (S)-5-hydroxythalidomide Authors : urihata,F H.; Miyauchi, Y.; Asano, A.; anokura,T M.; Miyakawa, T. Deposited on : 2020-03-25 Resolution : 1.80 Å(reported) This is a ullF wwPDB X-ray Structure alidationV Report for a publicly released PDB entry.
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header metal binding protein 25-mar-20 7bqv title cereblon in complex with sall4 and (s)-5-hydroxythalidomide compnd mol_id: 1; compnd 2 molecule: protein cereblon; compnd 3 chain: a; compnd 4 engineered: yes; compnd 5 mutation: yes; compnd 6 mol_id: 2; compnd 7 molecule: sal-like protein 4; compnd 8 chain: b; compnd 9 synonym: zinc finger ...
7bqv - Cereblon in complex with SALL4 and (S)-5 …
10.2210/pdb7bqv/pdb: Descriptor: Protein cereblon, Sal-like protein 4, 2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-5-oxidanyl-isoindole-1,3-dione, ... (6 entities in total) Functional Keywords: zinc finger, e3 ubiquitin ligase, complex, thalidomide, metal binding protein: Biological source: Homo sapiens (Human) More: Total number of ...
PDB Entry - 7BQV - wwpdb.org
PDB Entry - 7BQV (Status - Released) Summary information: Title: Cereblon in complex with SALL4 and (S)-5-hydroxythalidomide. PDB DOI: https://doi.org/10.2210/pdb7bqv/pdb. Primary publication DOI: https://doi.org/10.1038/s41467-020-18488-4. Entry authors: Furihata, H., Miyauchi, Y., Asano, A., Tanokura, M., Miyakawa, T. Initial deposition on ...