In molecular biology 7SK is an abundant small nuclear RNA found in metazoans. [1] It plays a role in regulating transcription by controlling the positive transcription elongation factor P-TEFb. [2] 7SK is found in a small nuclear ribonucleoprotein complex (snRNP) with a number of other proteins that regulate the stability and function of the ...

Dec 25, 2024 · RN7SK (RNA Component Of 7SK Nuclear Ribonucleoprotein) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with RN7SK include Acquired Immunodeficiency Syndrome and Immune Deficiency Disease. ... Cas9 Proteins, Cas9 Nuclease Vector/Virus, Cas9-Expressing Cell Lines also available.

Aug 2, 2024 · 本文主要介绍三种3型pol iii启动子7sk、u6和h1启动子的序列、转录起始位点及它们的一些特点。 加粗部分为tata盒，绿色背景为+1位 人7sk 启动子:

Mar 17, 2021 · 以往研究认为7SK RNP的主要功能是阻止正转录延伸因子b（P-TEFb）与染色质和RNA聚合酶II（RNAPII）结合，进而抑制RNAPII ser2的磷酸化及其转录停滞释放（Pausing release）3。

在人类细胞中，P-TEFb的非活性形式是与7SK snRNP结合的。P-TEFb可以被多种机制（Brd4、中介体或某些直接与DNA结合的激活剂）激活并募集到已暂停的Pol II复合物中。 磷酸化的NELF从Pol II上解离，DSIF被P-TEFb磷酸化后变成正延伸因子。

The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding genes and promotes transcription of RNA polymerase II-specific spliceosomal small nuclear RNA ...

Oct 10, 2023 · Human 7SK is an abundant and conserved 332-nucleotide small nuclear RNA (snRNA) that inhibits transcription elongation through negatively regulating P-TEFb kinase activity. 10,11,12 Specifically, 7SK forms small nuclear ribonucleoprotein (snRNP) complexes with several RNA-binding proteins to modulate RNA Pol II promoter-proximal pausing.

The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding …

Feb 24, 2021 · The noncoding RNA 7SK controls the transcription of mRNAs. Here, the authors show that the 7SK complex interacts with the Smn complex, suggesting crosstalk between transcription and snRNP...

2023年10月10日，美国佛罗里达大学的谢明艺教授团队在Molecular Cell 杂志在线发表了题为“N6-methyladenosine in 7SK small nuclear RNA underlies RNA polymerase II transcription regulation”，揭示了m6A通过调控7SK snRNA介导的转录延伸复合物 (pTEFb)的释放，从而调控了细胞的转录延伸，最终影响了细胞的整体转录水平。 研究人员首先通过MeRIP-qRCR实验系统比较了两组正常对照细胞和四组非小细胞肺癌（NSCLC）中7SK snRNA的修饰丰度，结果显示在 …