2016年2月15日 · Here we show that the 7SK small nuclear RNA (snRNA) inhibits enhancer transcription by modulating nucleosome position. 7SK occupies enhancers and super enhancers genome wide in mouse and human...

7SK adopts a distinct RNA secondary structure that enables its specific binding to BAF. Further experiments showed that the 7SK-BAF snRNP is localized at enhancers by an...

2019年5月15日 · NCBI's Gene Expression Omnibus (GEO) is a public archive and resource for gene expression data.

2016年3月18日 · 7SK is a small nuclear RNA (snRNA) that, as part of a specific small nuclear ribonucleoprotein (snRNP) complex, regulates promoter-proximal pausing during transcription. Using a series of...

7SK-Baf Axis Controls Pervasive Transcription at Enhancers. Flynn RA, Do BT, Rubin AJ, Calo E, Lee B, Kuchelmeister H, Rale M, Chu C, Kool ET, Wysocka J, Khavari PA, Chang HY (2016) Nat Struct Mol Biol. 2016 Feb 15.

Here we show that the 7SK small nuclear RNA (snRNA) inhibits enhancer transcription by modulating nucleosome position. 7SK occupies enhancers and super enhancers genome-wide in mouse and human cells, and 7SK is required to limit eRNA initiation and synthesis in a manner distinct from promoter pausing.

Clustered elements at super enhancers uniquely require 7SK to prevent convergent transcription and DNA-damage signaling. 7SK physically interacts with the BAF chromatin-remodeling complex, recruits BAF to enhancers and inhibits enhancer …

7SK-BAF axis controls pervasive transcription at enhancers. Nat Struct Mol Biol. 2016 Feb 15. doi: 10.1038/nsmb.3176.

The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding genes and promotes transcription of RNA polymerase II-specific spliceosomal small nuclear RNA g...

Clustered elements at super enhancers uniquely require 7SK to prevent convergent transcription of colliding polymerases that lead to DNA damage. 7SK inhibits enhancer transcription by modulating chromatin structure, physically interacts with the BAF chromatin remodeling complex, and is required to recruit BAF to enhancers.