In molecular biology 7SK is an abundant small nuclear RNA found in metazoans. [1] It plays a role in regulating transcription by controlling the positive transcription elongation factor P-TEFb. [2] 7SK is found in a small nuclear ribonucleoprotein complex (snRNP) with a number of other proteins that regulate the stability and function of the ...

The human 7SK ribonucleoprotein (RNP) has been analyzed to determine its RNA secondary structure and protein constituents. HeLa cell 7SK RNA alone and within its RNP have been probed by chemical modification and enzymatic cleavage, and sites of modification or cleavage have been mapped by primer extension.

LARP7是一种与哺乳动物细胞内丰度最高的长链非编码RNA-7SK RNA相结合的 La核糖核蛋白。 LARP7，MEPCE和7SK RNA一起组成7SK 核糖核蛋白复合体 （7SK RNP）的基本结构【2】。 以往研究认为7SK RNP的主要功能是阻止正转录延伸因子b（P-TEFb）与染色质和RNA聚合酶II（RNAPII）结合，进而抑制RNAPII ser2的磷酸化及其转录停滞释放（Pausing release）【3】。 LARP7是一种遗传疾病发病相关基因，在患有侏儒症和Alazami综合征的患者中均发现LARP7 …

2021年2月24日 · We found that Smn interacts with the 7SK core components Larp7 and Mepce and specifically associates with 7SK subcomplexes containing hnRNP R. The association between Smn and 7SK complexes is...

2022年5月5日 · The structures of 7SK core RNPs with linear and circular RNA conformations reported here, together with biochemical data, reveal a stepwise mechanism for the early RNP biogenesis events, where MePCE preferably caps and retains the nascent linear 7SK during RNA Pol III transcription, but the binding of Larp7 triggers the formation of circular ...

7sk 核糖核蛋白 (rnp) 是后生动物 rna 聚合酶 ii (rnapii) 转录的动态多功能调节剂。 由非编码 7SK RNA、核心蛋白和众多辅助蛋白组成，最著名的 7SK RNP 功能是正转录延伸因子 b (P-TEFb) 的隔离和失活。

2018年12月17日 · Among RNA 5′-cap structures, γ-phosphate monomethylation is unique to a small subset of noncoding RNAs, 7SK and U6 in humans. 7SK is capped by methylphosphate capping enzyme (MePCE), which has...

Human 7SK RNA is an abundant 331-nucleotide-long, evolutionarily conserved small nuclear RNA (snRNA) that, in the form of 7SK small nuclear RNP (snRNP), regulates RNA polymerase II (RNAPII) transcription through controlling the activity of a …

2022年5月5日 · 7SK non-coding RNA (7SK) negatively regulates RNA polymerase II (RNA Pol II) elongation by inhibiting positive transcription elongation factor b (P-TEFb), and its ribonucleoprotein complex (RNP) is hijacked by HIV-1 for viral transcription and replication.

Comprised of the non-coding 7SK RNA, core proteins, and numerous accessory proteins, the most well-known 7SK RNP function is the sequestration and inactivation of the positive transcription elongation factor b (P-TEFb). More recently, 7SK RNP has been shown to regulate RNAPII transcription through P-TEFb-independent pathways.