We demonstrate that 9p21 loss confers “cold” tumor-immune phenotypes, characterized by reduced abundance of tumor-infiltrating leukocytes (TILs), particularly, T/B/NK cells, altered …

9p21区域是人类多种肿瘤中经常出现纯合缺失或杂合缺失的染色体区域。 CDKN2B的失活可能导致细胞生长和增殖失控，导致癌症发生。 CDKN2A/2B的共失活是 Rb蛋白 磷酸化和致癌基因 …

2008年12月1日 · Within a few weeks, 4 independent genomewide association studies reported the association of the same locus on chromosome 9p21 with coronary artery disease (CAD) …

近日，一篇发表在国际杂志Nature上题为“SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO”的研究报告中，来自哈佛大学-麻省理工学院的 ...

The 9p21 variant became the first risk factor to be identified since 1964. 9p21 occurs in 75% of the population except for African Americans and is associated with a 25% increased risk for …

We demonstrate that 9p21 loss confers "cold" tumor-immune phenotypes, characterized by reduced abundance of tumor-infiltrating leukocytes (TILs), particularly, T/B/NK cells, altered …

Single nucleotide polymorphisms (SNPs) on chromosome 9p21 are associated with coronary artery disease, diabetes, and multiple cancers. Risk SNPs are mainly non-coding, suggesting …

2025年1月3日 · CDKN2A is a tumor suppressor located in chromosome 9p21 and frequently lost in Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC). How CDKN2A and other …

2011年8月18日 · Common variation at chromosome 9p21 (marked by rs10757278 or rs1333049) is associated with coronary artery disease (CAD) and peripheral vascular disease. A …

The 9p21 gene has been shown to be an independent predictor of cardiovascular risk. Carriers have a 1.5-2.0 fold increased risk of cardiovascular disease (particularly stroke and abdominal …