Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in stress responses.

时光荏苒，接触过多种国内国外EDC系统、中文英文纸质CRF，也同时接触到不同的AE填写规则，本文仅以笔者所见所思且以自身工作角度出发讨论AE填写一些观点。 AE填写规则. i)总结式填写. 简单来说，AE记录最高级别，以AE首次发现时间填写AE开始时间。 此种填写方式是笔者最早接触到到的一种填写规则。 现在想起来此种填写方式着实“大智若愚”。 ii)以AE级别改变填写. 每当AE级别发生变化，重新填写一次AE。 该种填写方式是笔者接触到的比较“深恶痛绝”的一种填写方 …

CRF01_AE represents a putative subtype A/E recombinant that is spreading epidemically in Asia, but originated from Central Africa (Murphy et al. 1993; Carr et al. 1996; Gao et al. 1996). No 'pure' full-length genome has been found for subtype E.

An eCRF (electronic case report form) is a digital questionnaire that is used to collect data about a clinical study and research participants. The data collected in eCRFs is what biostatisticians analyze to draw a conclusion from a study.

In oncology clinical trials, the AE severity is usually graded according to NCI’s AE Severity Grading Scale - Common Terminology Criteria for Adverse Events (CTCAE). CTCAE can also be used to grade the AE for non-oncology studies, but generally not appropriate for studies using healthy volunteers.

The CDASHIG AE domain includes clinical data describing "any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have to have a causal relationship with this treatment" (ICH E2A).

2024年12月3日 · Notably, silencing the expression of the corticotropin-releasing factor (CRF) within the medial prefrontal cortex (mPFC) attenuates the impact of stress self-experience on the reaction to others’...

2019年12月1日 · Cytokinin Response Factors (CRFs) are a family of transcription factors which make up a side branch of the classical cytokinin two-component signaling pathway. CRFs were originally identified and have been primarily studied in Arabidopsis thaliana, although orthologs have be found throughout all land plants.

1996年4月1日 · Corticotrophin-releasing factor (CRF) acts within both the brain and the periphery to coordinate the overall response of the body to stress. The involvement of the CRF systems in a variety of both CNS and peripheral disease states has stimulated great interest in this peptide as a potential site of therapeutic intervention.

2016年1月5日 · 摘要: CRF01_AE是我国目前流行的主要HIV-1毒株,具有独特的流行病学特征。 本文从该毒株的发现起源与命名、在国内外的流行过程、参与形成的重组毒株以及致病性等方面进行介绍,并讨论了与流行病学特征密切相关的社会和生物学因素。 Abstract: CRF01_AE has been the major HIV-1 strain circulating in China with unique epidemiological features.