2014年2月12日 · This specific mutation in SLC24A5, called A111T, is found in virtually everyone of European ancestry. A111T is also found in populations in the Middle East and Indian subcontinent, but not in high numbers in Africans.

2020年12月27日 · The allele, A111T, rs1426654 (A), indicates light-skinned West Eurasian ancestry. [PMID 16847698, PMID 16357253]

A111T shows a latitudinal decline toward the Equator, with high frequencies in Northern Africa (>0.80), intermediate (0.4−0.6) in Ethiopia and Somalia, and lower (<0.35) in sub-Saharan Africa. This pattern is broadly consistent with strong positive selection for decreased skin pigmentation throughout Europe.

研究发现一种被命名为A111T的突变，对浅色皮肤遗传表观具有决定意义，存在于每位欧洲人基因中，同时也存在于中东、北非、东非和南印度地区居民。

2014年1月9日 · Divergent natural selection caused by differences in solar exposure has resulted in distinctive variations in skin color between human populations. The derived light skin color allele of the SLC24A5 gene, A111T, predominates in populations of Western Eurasian ancestry.

NCKX5 is a bidirectional K + -dependent Na + -Ca 2+ exchanger, which belongs to the SLC24A gene family. In particular, the A111T mutation of NCKX5 has been associated with reduced pigmentation in European populations.

2013年11月6日 · The derived light skin color allele of the SLC24A5 gene, A111T, predominates in populations of Western Eurasian ancestry. To gain insight into when and where this mutation arose, we defined common haplotypes in the genomic region around SLC24A5 across diverse human populations and deduced phylogenetic relationships between them.

2015年2月14日 · 研究表明，欧洲人浅色皮肤起源于一万年前的一位祖先的基因突变，SLC24A5基因中的A111T突变在染色体15上，对欧洲人皮肤颜色有显著影响。

2025年2月8日 · All chromosomes carrying the A111T allele of SLC24A5 gene share a single 78-kb haplotype indicating that all instances of this mutation in human populations share a common origin. We observed a heterogeneous phenotype among seven oculocutaneous albinism patients with SLC24A5 mutations.

2014年1月9日 · The derived light skin color allele of the SLC24A5 gene, A111T, predominates in populations of Western Eurasian ancestry. To gain insight into when and where this mutation arose, we defined common haplotypes in the genomic region around SLC24A5 across diverse human populations and deduced phylogenetic relationships between them.