2019年5月13日 · We provide genetic evidence that RIPK1 kinase-dependent, RIPK3–MLKL-mediated necroptosis drives inflammasome activation in A20-deficient macrophages and …

2014年7月16日 · In this study, we investigated the brain phenotype of A20 heterozygous (HT) and knockout (KO) mice. Methods: The inflammatory status of A20 wild type (WT), HT and KO …

2024年4月12日 · A20 myel-KO mice are characterized by persistent Trichuris muris infection and intestinal inflammation. Myeloid A20 deficiency induces strong classical macrophage …

2014年6月29日 · These results reveal A20 as a novel negative regulator of Nlrp3 inflammasome activation, and describe A20myel-KO mice as the first experimental model to study the role of …

2014年8月7日 · Rheumatoid arthritis in A20 (myel-KO) mice is not rescued by deletion of tumour necrosis factor receptor 1 (ref. 2). Here we show, however, that it crucially relies on the Nlrp3 …

2018年5月23日 · Here we demonstrate that the nuclear factor kappa B (NF-κB) regulatory protein A20 is crucial in regulating microglia activation during CNS homeostasis and pathology. In …

2024年4月12日 · We infect A20 myel-KO mice with the gastrointestinal helminth Trichuris muris and we analyzed the innate and adaptive responses. We performed RNA sequencing on …

2021年9月21日 · Nuclear factor κB (NF-κB) signaling is a central coordinator of inflammatory responses and is tightly regulated by the anti-inflammatory protein A20. Here, we find that …

2014年7月16日 · In this study, we investigated the brain phenotype of A20 heterozygous (HT) and knockout (KO) mice. The inflammatory status of A20 wild type (WT), HT and KO brain was …

2013年11月17日 · Instead, A20 E-KO mice display keratinocyte hyperproliferation, and develop ectodermal organ abnormalities, including dishevelled hair, longer nails, and sebocyte …