The adenosine A2A receptor, also known as ADORA2A, is an adenosine receptor, and also denotes the human gene encoding it. [5][6] This protein is a member of the G protein-coupled …

Adenosine A2A Receptor is a subtype of adenosine receptors that is Gs-protein-coupled and can increase intracellular cAMP levels, predominantly found in immune cells where it plays a role …

Adenosine initiates its biological effects via four receptor subtypes, namely the A 1, A 2A, A 2B and A 3 ARs. The A 1 and A 2A AR possess high affinity for adenosine while the A 2B and A 3 …

2017年12月14日 · Over a decade of research and innovation has culminated with the publication of more than 30 crystal structures of the human adenosine A 2A receptor (A 2A R), making it …

2013年10月28日 · Herein we describe adenosine A 2A receptor distribution, signaling pathways, pharmacology, and molecular structure, followed by a summary and SAR discussion of the …

2016年5月4日 · Here we use 19F nuclear magnetic resonance to quantify the conformational landscape occupied by the adenosine A2A receptor (A2AR), a prototypical class A G-protein …

2014年5月8日 · Herein we describe adenosine A2A receptor distribution, signaling pathways, pharmacology, and molecular structure, followed by a summary and SAR discussion of the …

This review provides an update of the latest A2A receptor agonists developed in the period 2005-2017, their selectivity regarding other adenosine receptors and their potential therapeutic …

2023年11月30日 · We utilize fluorescence imaging at the single-molecule level to visualize the dynamic process of CAM-mediated activation of the human A 2A adenosine receptor (A 2A …

2017年12月14日 · In this review we analyze the structural data reported for A 2A R that described for the first time the binding of mode of antagonists, including newly developed drug …