Pore-forming toxin-mediated ion dysregulation leads to death …
2017年4月7日 · That necroptosis was activated in cells experiencing Ca ++, and K + dysregulation was verified by detection of pMLKL in ionomycin- and nigericin-challenged A549 …
DNA damage-inducible transcript 3 positively regulates RIPK1 …
2024年10月3日 · DNA damage-inducible transcript 3 (DDIT3) is a well-known transcription factor that regulates the expression of apoptosis-related genes for promoting apoptosis during …
Bacterial Pore-Forming Toxins Promote the Activation of ... - Nature
2018年4月11日 · Herein, we show that respiratory epithelial cells (REC) undergoing bacterial pore-forming toxin (PFT)-induced necroptosis simultaneously experienced caspase activation …
Initiator cell death event induced by SARS-CoV-2 in the human …
2024年7月12日 · We then assessed the presence of pMLKL in A549-ACE2-TMPRSS2 cells at 24 HPI and found pMLKL in the cells infected with either Delta or Omicron (fig. S7H). As …
Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis - Cell …
2020年3月19日 · Here, we show that replicating IAV generates Z-RNAs, which activate ZBP1 in the nucleus of infected cells. ZBP1 then initiates RIPK3-mediated MLKL activation in the …
CNS前沿文献追踪 – 追踪程序性坏死过程中MLKL行为|pMLKL|程序 …
2020年6月29日 · 作者又用NSA封住MLKL和膜互作的位点，发现NSA抑制了MLKL的寡聚、膜转位、pMLKL聚集成hotspots，最终抑制了膜损伤，且NSA加入的越早抑制作用越强，暗示MLKL …
Osteopontin mediates necroptosis in lung injury after …
2019年10月1日 · Expression of osteopontin (OPN) and endoplasmic reticulum (ER) stress, OPN and receptor-interacting protein (RIP)1, and phosphorylated mixed lineage kinase domain-like …
MLKL-PITPα signaling-mediated necroptosis contributes to ... - PubMed
2018年2月1日 · In this study, we show that apart from apoptosis, cisplatin induces necroptosis in A549 cells. The alleviation of cell death by two necroptosis inhibitors-necrostatin-1 (Nec-1) and …
MLKL contributed to the CHE-induced antiproliferation
ROC curve revealed a high predictive value of pMLKL score at T1 (AUC 0.70) and the ratio of pMLKL score at T1 and T0 (pMLKL-index, AUC 0.82) for EAD. Liver grafts with a high pMLKL …
molecular mechanisms of MLKL-dependent and MLKL-independent necrosis ...
2020年10月16日 · Mixed lineage kinase domain-like pseudokinase (MLKL) is considered to be the key mediator of necroptosis. After necroptosis initiation, MLKL together with RIP1 and …