Adeno-Associated Virus Serotype-Specific Inverted Terminal Repeat ...
Here, various cell lines were infected with AAV vectors containing the ITR sequences from AAV serotypes 1, 2, 3, 4, 6, and 7 and their ability to promote luciferase expression was measured …
Deletion of the B-B’ and C-C’ regions of inverted terminal ... - Nature
2017年7月14日 · This study suggests deletion in ITR can affect the transgene expression of AAV, which provides a new way to improve the AAV expression through ITRs modification.
Mechanism of Rep-Mediated Adeno-Associated Virus Origin Nicking
The single-stranded adeno-associated virus type 2 (AAV) genome is flanked by terminal repeats (TRs) that fold back on themselves to form hairpinned structures. During AAV DNA replication, …
Rep-mediated nicking of the adeno-associated virus origin ... - PubMed
The single-stranded adeno-associated virus (AAV) genome is flanked by terminal hairpinned origins of DNA replication (terminal repeats [TRs]) that are nicked at the terminal resolution …
Hairpin-end conformation of adeno-associated virus genome
2012年11月15日 · In recombinant AAV (rAAV) gene-delivery vectors, they are targets for the DNA-repair pathways leading to circularization, concatemerization and, infrequently, …
Sequence alignment of the RBS and TRS of the AAV2 ITR
The adeno-associated virus (AAV) inverted terminal repeats (ITRs) contain the AAV Rep protein-binding site (RBS) and the terminal resolution site (TRS), which together act as a minimal origin...
Rep-Mediated Nicking of the Adeno-Associated Virus Origin …
1999年6月8日 · The single-stranded adeno-associated virus (AAV) genome is flanked by terminal hairpinned origins of DNA replication (terminal repeats [TRs]) that are nicked at the terminal …
ITR结构对腺相关病毒（AAV）产量的影响 - Pharmcube
2024年3月13日 · 金斯瑞蓬勃生物是中国首个细胞基因治疗载体CDMO供应商及中国领先的慢病毒载体（LVV），腺相关病毒载体（AAV）供应商，拥有稳定且高产的病毒载体平台，并且，金 …
A novel terminal resolution-like site in the adeno-associated virus ...
The adeno-associated virus 2 (AAV) contains a single-stranded DNA genome of which the terminal 145 nucleotides are palindromic and form T-shaped hairpin structures. These inverted …
Adeno-associated virus terminal repeat (TR) mutant generates self ...
2003年11月17日 · Palindromic terminal repeat (TR) structures at each end of the genome serve as primers for host-cell-mediated synthesis of the complementary DNA strand...