The Kidd antigen system (also known as Jk antigen) are proteins found in the Kidd's blood group, which act as antigens, i.e., they have the ability to produce antibodies under certain circumstances. The Jk antigen is found on a protein responsible for urea transport in the red blood cells and the kidney. [ 1 ]

Anti Jk a antibody was identified in eluate obtained from neonatal red cells by heat elution method. On red cell phenotyping, mother was found to be Jk a antigen negative; father and neonate were found to be Jk a antigen positive. Antibody was observed to be of IgG type on Dithiothreitol (DTT) treatment.

Anti-Jk-a and anti-Jk-b are IgG antibodies (incomplete) that form in respective antigen-negative persons following exposure by transfusion or pregnancy (immune antibodies). These antibodies, however, activate complement in a much more efficient way than other IgG antibodies resulting in a greater likelihood of intravascular hemolytic ...

In this review, we will outline the makeup of the Kidd system from its historical discovery to the details of the Kidd gene and glycoprotein, and then discuss the practical aspects of Kidd antibodies and transfusion reactions with an extended focus on the Kidd-null phenotype.

2017年7月1日 · Four Kidd phenotypes are possible: Jk (a+b−), Jk (a−b+), Jk (a+b+), and Jk (a−b−). The Jk3 antigen is high incidence and clinically relevant in Kidd-null individuals. Polynesians most commonly have an increased prevalence of the Kidd-null phenotype. Kidd blood group system antibodies cause acute and delayed hemolytic reactions.

Anti-Jk a has occasionally been found as an autoantibody, and the concurrent, temporary suppression of antigen expression has also been reported. 59 Anti-Jk3, sometimes referred to as anti-Jk ab, is produced by Jk(a–b–) individuals and reacts with RBCs that are positive for Jk a, …

Kidd blood group system, classification of human blood based on the presence of glycoproteins known as Kidd (Jk) antigens on the surfaces of red blood cells. The Kidd glycoprotein functions to maintain the osmotic stability of red blood cells by acting as a transporter of urea .

THE human blood-group system called Kidd was discovered in 1951 by Allen, Diamond and Niedziela 1, who found an antibody, anti-Jk a, which distinguished two phenotypes, Jk(a+) and Jk(a−).

2015年8月1日 · We review the expression of Kidd antigens and the development and detection of Kidd antibodies, and discuss the case reports from the literature of Kidd antibodies associated with kidney-graft rejection that suggest Kidd antigens play a …

2020年4月29日 · The two antigens Jk a and Jk b result from the substitution of a single amino acid that then leads to three common phenotypes: Jk (a+b-), Jk (a-b+), and Jk (a+b+); The final phenotype, Jk (a-b-) is also called the null phenotype but this is rare in whites and African Americans, but is found with increased frequency in Asian and polynesian indivi...