There are two major biologically distinct molecular subtypes of DLBCL: germinal center B-cell (GCB) and activated B-cell (ABC). ABC DLBCL is associated with substantially worse …

2018年4月11日 · Diffuse large B-cell lymphomas (DLBCLs) are phenotypically and genetically heterogeneous. Gene-expression profiling has identified subgroups of DLBCL (activated B …

PMBL is a distinct subtype of DLBCL with characteristic clinical and pathologic features, including a gene expression pattern more closely resembling NSHL than GCB DLBCL or ABC DLBCL. …

We identify specific, activated B cell-like (ABC) and germinal center B cell-like (GCB) distinguishing genes. These include early (e.g. CDKN3) and late (e.g. CDKN2C) cell cycle …

The aim of the present study was to assess the accuracy of each of the 4 most commonly-used and relatively easy-to-perform algorithms in classifying patients into the ABC and GCB …

2020年3月24日 · Diffuse large B-cell lymphoma (DLBCL) is a heterogenous blood cancer, but can be broadly classified into two main subtypes, germinal center B-cell-like (GCB) and activated B …

2019年1月1日 · Gene expression profiling (GEP) separated diffuse large B-cell lymphoma (DLBCL) in two different entities, i.e. activated B cell-like (ABC) and germinal center B cell-like …

There are two major biologically distinct molecular subtypes of DLBCL: germinal center B-cell (GCB) and activated B-cell (ABC). ABC DLBCL is associated with substantially worse …

In this review, we present an in-depth study of the differences between the two main DLBCL subsets (germinal center B cell [GCB] and ABC), focusing specifically on their different genetic …

Compared with patients who had GCB DLBCL, those with ABC DLBCL had a much higher overall response rate (83% vs 13%; P = .0004) as well as an improved median overall survival (10.8 …