ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA), also known as the cholesterol efflux regulatory protein (CERP) is a protein which in humans is encoded by the ABCA1 gene. [5] This transporter is a major regulator of cellular cholesterol and phospholipid homeostasis.

此外，abca1的表达与几个sasp基因呈正相关，包括人类oa样本中的mmp13、il1b和il8，表明abca1在体内sasp调节中的潜在保守作用。 首先检查了胆固醇代谢和Abca1在原代小鼠软骨细胞中的作用，其衰老已被证明能促进OA的发展。

2024年12月24日 · ABCA1 (ATP Binding Cassette Subfamily A Member 1) is a Protein Coding gene. Diseases associated with ABCA1 include Tangier Disease and Hypoalphalipoproteinemia, Primary, 1. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Cholesterol metabolism.

ABCA1由两个包含六个跨膜段和一个大的糖基化胞外结构域的单元串联组成。它在全身广泛表达，在巨噬细胞中有特别重要的作用，能帮助清除多余胆固醇，防止它们转化成泡沫细胞，因而具有保护动脉粥样硬化的功能。人ABCA1基因突变会引起Tangier病。

ABCA1的胞外区形成了一个非常独特的结构，其中包含了一个长的疏水孔道(elongated hydrophobic tunnel)，为进一步的功能研究提供了非常关键的线索。ABCA1的高分辨率结构，也为理解之前大量疾病突变的致病机制提供了重要基础。

Pancreatic β-cell specific Abca1 KO mice (Abca1-P/-P) showed age-related and gene-dose-dependent accumulation of cholesterol in β-cells. In addition, these mice showed significantly decreased insulin secretion in response to an acute glucose challenge in vivo, along with progressive glucose tolerance impairment, which was not related to islet ...

ABCA1 functions as a lipid transporter because it mediates the transfer of cellular phospholipid (PL) and free (unesterified) cholesterol (FC) to apoA-I and related proteins present in the extracellular medium. ABCA1 is a membrane PL translocase and ...

2022年8月16日 · ATP-binding cassette transporter A1 (ABCA1) drives phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I, for the production of high density...

ATP-binding cassette transporter A1 (ABCA1) is a transmembrane transporter protein ubiquitously expressed in human tissue, and found in abundance in the liver and lungs. ATP 结合盒转运蛋白 A1 (ABCA1) 是一种在人体组织中普遍表达的跨膜转运蛋白，在肝脏和肺中大量存在。

在这篇综述中，我们首先讨论了 abca1 结构、组织分布、细胞定位和运输及其功能。 此外，总结了目前对 ABCA1 表达调控所涉及的分子机制的理解。 ABCA1转录调控是由一个非常复杂的系统介导的，包括核受体系统、与ABCA1启动子其他位点结合的因子、细胞因子 ...