Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9.

2024年12月24日 · ABL1 (ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ABL1 include Congenital Heart Defects And Skeletal Malformations Syndrome and Leukemia, Chronic Myeloid.

The ABL1 gene provides instructions for making a protein involved in many processes in cells throughout the body. The ABL1 protein functions as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions.

The Abl family of cytoplasmic tyrosine kinases consists of 2 members, Abl and Arg (Abl-related gene), encoded by the ABL1 and ABL2 genes in humans, and has important roles in various biological processes. 1,2 Abl kinases share a central SH2-kinase domain unit with the majority of other cytoplasmic kinases 3 and have a long C-terminal tail ...

The mammalian ABL1 gene encodes the ubiquitously expressed nonreceptor tyrosine kinase ABL. In response to growth factors, cytokines, cell adhesion, DNA damage, oxidative stress, and other signals, ABL is activated to stimulate cell proliferation or differentiation, survival or …

The ABL protein, alternatively referred to as Abelson proto-oncogene, is a tyrosine kinase protein that assumes a pivotal function in cellular signalling and regulation [11]. The ABL1 gene, situated on chromosome 9 in humans, is responsible for its encoding.

Gene ID: 25, updated on 20-Feb-2025. This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress.

2025年2月9日 · This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene.

2024年12月24日 · ABL2 (ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ABL2 include Leukemia, Acute Lymphoblastic and Hematologic Cancer. Among its related pathways are Nervous system development and Signaling by Rho GTPases.

A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.