TUDCA treatment inhibits NF-κB pathway and increases further TGF-β pathway favoring the resolution of the inflammatory process. The anti-inflammatory environment promoted by glial cells might lead to an increase of neuronal survival and a faster restoration of …

Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid containing taurine conjugated with the ursodeoxycholic acid (UDCA), has been known and used from ancient times as a therapeutic compound in traditional Chinese medicine. TUDCA has recently been gaining significant interest as a neuroprotective agent, also exploited in the visual disorders.

Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA), a US Food and Drug Administration–approved hydrophilic bile acid for the treatment of certain cholestatic liver diseases. There is a growing body of research ...

As an FDA-approved drug for chronic cholestatic liver diseases, tauroursodeoxycholic acid (TUDCA), a natural bile acid, offers additional health benefits beyond liver protection. Here, we show that TUDCA extends the lifespan and healthspan of C. elegans.

2023年11月16日 · Phase II studies on tauro-urso-deoxycholic acid (TUDCA) raised the promise of safety and efficacy in patients with amyotrophic lateral sclerosis, a currently incurable and devastating disease.

Background and purpose: Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity.

2023年6月29日 · Current evidence points to a protective effect of TUDCA in ALS, alone or combined with phenylbutyrate (PB) at dosages of 2000 mg/daily, in slowing disease progression and prolonging survival in post-hoc analysis of two phase II clinical trials.

2022年9月27日 · Enrolled patients are randomized to one of two treatment arms: TUDCA or identical placebo by oral route. The study measures disease progression during the treatment period and compares it to natural progression during a no-treatment run-in phase. Clinical data and specific biomarkers are measured during the trial.

Bile acids are produced in the liver and excreted into the intestine, where their main function is to participate in lipid digestion. Ursodeoxycholic acid (UDCA) and tauroursodeoxycholic acid (TUDCA) have shown antiapoptotic, anti-inflammatory, and ...

2024年11月18日 · Preclinical studies have shown that TUDCA is neuroprotective, anti-inflammatory, antidiabetic, and has many more health-promoting properties. 1. Reduces bile sludge (cholestasis) TUDCA has been found in clinical trials to have strong effects as bile acids, improving cholestasis by reducing bile sludge.