A Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c is a protein that in humans is encoded by the ADAM10 gene. [5] Members of the ADAM family are cell surface proteins with a unique structure, possessing both potential adhesion and protease domains.

2024年12月24日 · ADAM10 (ADAM Metallopeptidase Domain 10) is a Protein Coding gene. Diseases associated with ADAM10 include Reticulate Acropigmentation Of Kitamura and Alzheimer Disease 18. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

2025年2月8日 · ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion. ADAM10-cleaved ephrin-A5 contributes to prostate cancer metastasis. Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.

Human ADAM10 is localized on chromosome 15 (15q22) and is widely expressed in mammalian organs, including brain. The role of ADAM10 as α-secretase cleaving APP has been confirmed by overexpression in intact cells, which leads to a several-fold increase in …

2025年1月23日 · A Disintegrin and Metalloprotease 10, also known as ADAM10, is a cell surface protease ubiquitously expressed in mammalian cells where it cuts several membrane proteins implicated in multiple physiological processes. The dysregulation of ADAM10 ...

As a member of the A Disintegrin And Metalloproteinase (ADAM) family, ADAM10 has been identified as the constitutive α-secretase in the process of amyloid-β protein precursor (AβPP) cleavage and plays a critical role in reducing the generation of the amyloid-β (Aβ) peptides.

We will discuss some examples of ADAM10 activity modulated by changing partners and subcellular compartmentalization, with the underlying hypothesis that restraining protease activity by spatial segregation is a complex and powerful regulatory tool.

2018年9月21日 · This study shows that ADAM10 is the receptor for the staphylococcal toxin α-haemolysin in vivo and identifies ADAM10 activity as a novel therapeutic target for α-haemolysin-induced disease.

The ubiquitously expressed transmembrane protein a disintegrin and metalloproteinase 10 (ADAM10) functions as a “molecular scissor”, by cleaving the extracellular regions from its membrane protein substrates in a process termed ectodomain shedding.

2020年3月24日 · Generating inhibitors for A Disintegrin And Metalloproteinase 10 (ADAM10), a zinc-dependent protease, was heavily invested in by the pharmaceutical industry starting over 20 years ago.