A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene. [5][6] ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.

2024年12月24日 · ADAMTS5 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5) is a Protein Coding gene. Diseases associated with ADAMTS5 include Osteoarthritis and Bone Deterioration Disease. Among its related pathways are O-linked glycosylation of mucins and Endochondral ossification with skeletal dysplasias.

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We here provide an updated insight on the regulation of ADAMTS5 and newly discovered therapeutic strategies for OA.

Adamts5-/-Mice Exhibit Increased Weight Loss and Delayed Influenza Virus Clearance following Infection. To investigate the role of ADAMTS5 in influenza virus infection, we initially examined in vivo weight loss and lung virus replication kinetics following infection.

2025年2月19日 · ADAMTS-5 is the key protease for versican regulation in murine aortas undergoing dilatation and extracellular matrix remodeling in model of thoracic aortic aneurysms. Since only two of the collected studies referred to ADAMTS4, we did not perform meta-analysis for these comparisons.

ADAMTS-4 (aggrecanase-1) and ADAMTS-5 (aggrecanase-2) are vital members of the ADAMTS metalloproteinase family, which participate in cartilage degradation and cleavage of the IGD domain’s Glu373-Ala374 bond in aggrecan . ADAMTS-4 is chiefly expressed in the OA cartilage, and ADAMTS-5 is expressed in both OA and healthy cartilage tissues.

This review reveals that both ADAMTS-4/ADAMTS-5 are responsible for aggrecan degradation in a human model of OA, and is expected to list down the rational strategies which are being focussed for therapeutic intervention in OA.