2024年12月24日 · ADAMTS1 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 1) is a Protein Coding gene. Diseases associated with ADAMTS1 include Primary Ovarian Insufficiency and Chondrosarcoma. Among its related pathways are O-linked glycosylation of mucins and Endochondral ossification with skeletal dysplasias.

A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene. [5][6] This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family.

2018年8月30日 · Our results confirmed a pro-inflammatory landscape in the absence of ADAMTS1, correlating with tumour blockade, supporting its novel role as a modulator of the immune cell response. The...

ADAMTSL1/Punctin Protein, Human (sf9, His) 是重组的 ADAMTSL1/Punctin 蛋白，由 Sf9 insect cells 表达，带有 C-His 标签。 ADAM8 蛋白被认为参与白细胞外渗，表明其在促进白细胞从血管迁移到周围组织中的潜在作用。 这意味着 ADAM8 通过调节白细胞穿过内皮屏障的运动来促进免疫反应，这是炎症和免疫监视过程中的关键一步。

2013年11月15日 · Elevated ADAMTS1 promotes pro-tumorigenic changes such as increased tumor cell proliferation, inhibited apoptosis and altered vascularization. Importantly, it facilitates significant peritumoral remodeling of the extracellular matrix environment to promote tumor progression and metastasis.

Adamts1 acts as an extracellular matrix 'modifier', with miR-181d-induced downregulation, that regulates adipocyte lineage commitment and obesity. This study showed that ADAMTS1, 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis.

含Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶ADAMTSs (a disintegrin and metallo-proteinase with thrombospondin...

adamts1是一种新型基质金属蛋白酶，对细胞外基质重建非常重要。 研究表明ADAMTS1在肥胖小鼠皮下脂肪组织表达下降，但具体机制还不清楚。 本项目首次发现在多潜能干细胞向前脂肪细胞定向过程中ADAMTS1表达明显降低，同时伴有细胞外基质组成改变。

含Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶ADAMTSs (a disintegrin and metallo-proteinase with thrombospondin motifs)是一类新的Zn2+依赖的金属蛋白酶家族,广泛存在于哺乳动物和无脊椎动物体内.从1997年发现第一个ADAMTSs家族成员以来,迄今共有19个成员被发现,在保持凝血系统的稳态,器官生成,炎症,生育等方面有重要作用.尽管其中大部分酶的功能尚不清楚,但已有研究显示该家族成员与多种疾病密切相关.ADAMTSs与基质金属蛋白酶MMPs,解聚蛋白样金属 …

与人ADAMTS1（具有血栓素类型1基序的ADAM金属肽酶1）正同源。 [由基因组资源联盟，2022年4月提供] Genome sequence of the Brown Norway rat yields insights into mammalian evolution. 预测能够实现肝素结合活性以及金属内肽酶活性。 参与几个过程，包括细胞对激素刺激的响应；细胞对维生素D的响应；以及牙齿萌发。 位于含有胶原的细胞外基质中。 脑缺血；心肌梗死；短暂性脑缺血；输尿管梗阻；以及视觉癫痫的生物标志物。 与人ADAMTS1（具有血栓素 …