A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene. [5][6] ADAMTS5 is a member of …

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We …

2024年12月24日 · ADAMTS5 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5) is a Protein Coding gene. Diseases associated with ADAMTS5 include Osteoarthritis and Bone …

Our research emphasises the importance of ADAMTS5 expression in the control of influenza virus infection and highlights the potential for development of ADAMTS5-based therapeutic …

ADAMTS5 is unequivocally implicated in pathogenesis of osteoarthritis via degradation of aggrecan, a major structural proteoglycan in cartilage. ADAMTS7 is strongly associated with …

2025年2月19日 · ADAMTS5 is hypermethylated and inhibits cancer cells invasion and migration in colorectal cancer, and correlates with OS and DFS. Development of a monoclonal anti …

Domain mapping and mechanistic studies revealed that ADAMTS5 inhibits B16 tumorigenesis through its TSR1 by suppressing tumor angiogenesis, likely by down-regulating pro …

2011年6月1日 · Since its discovery in 1999 the chondroitin sulphate proteoglycanase ADAMTS5 (aggrecanase-2, ADAMTS11) has emerged as a major drug target in osteoarthritis. However, …

2021年8月9日 · As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We here provide an updated insight on …

The major proteoglycan in the extracellular matrix—aggrecan—is primarily cleaved by the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of genes.1 …