2025年2月10日 · In this study, we demonstrate that highly expressed ADAR1 is a crucial oncogenic target in PCa and develop an effective small-molecule ADAR1 inhibitor, ZYS-1, with marked antitumor efficacy and...

Nicholas Haining教授团队发现小鼠中ADAR1缺失(Adar1-null)的黑色素瘤模型对抗PD1治疗更敏感。 在Adar1-null肿瘤微环境中，抗肿瘤效应的CD8+T细胞和NK细胞比例明显增加，而与免疫抑制相关的细胞减少。

2023年1月4日 · On July 20, 2022, Nature published three papers on ADAR1 regulating abnormal immune activation through the canonical A-to-I RNA editing pathway. 1, 2, 3 The study by Nicholas et al. demonstrated...

2024年12月30日 · adar1是一种双链rna（dsrna）上的腺苷脱氨酶，可以将腺苷（a）转化为肌苷（i），这一过程被称为a-to-i编辑。adar1的缺失或功能障碍会导致严重的炎症反应，而其在肿瘤细胞中则起到促进肿瘤进展和免疫逃逸的作用。因此，adar1成为了药物开发的一个新兴靶点。

2024年12月24日 · ADAR1 Luciferase Reporter-HEK293 细胞对 Fludarabin-Cl 的剂量反应。 用增加剂量的 Fludarabin-Cl 处理细胞 30 小时，并使用双重荧光素酶（萤火虫-海肾）测定系统测量萤火虫和海肾荧光素酶活性。

2024年12月24日 · Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication.

2024年7月18日 · ADAR1 is a promising target for cancer therapy. ADAR1 loss synergises with the antitumour effects of immune checkpoint blockade and epigenetic therapies. Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-stranded RNA (dsRNA) molecules, a process known as A-to-I editing.

2015年3月9日 · Nature Communications - ADAR1 is an adenosine deaminase that converts adenosine to inosine (A-to-I) mostly on Alu repeats in human RNA. Here by analysing transcriptome-wide ADAR1–RNA...

Recent studies show that editing-dependent functions of ADAR1 protect dsRNA from dsRNA-sensing molecules and inhibit innate immunity and the interferon-mediated response.

2025年1月1日 · ADAR1 is a promising target for cancer therapy. ADAR1 loss synergises with the antitumour effects of immune checkpoint blockade and epigenetic therapies. Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-stranded RNA (dsRNA) molecules, a process known as A-to-I editing.