2016年6月17日 · 生物导弹中的新秀---Biparatopic ADC 毒素分子和特异性抗体偶联在一起，这些特异性的抗体能够只与癌细胞表面特有的受体结合并被内吞入细胞内部，与此同时毒素分子也会被携带进细胞内，在胞内一些酶的作用下毒素分子会被释放，进而发挥杀伤作用，杀死癌细胞。

2018年12月1日 · Amongst the most advanced applications of mAbs, antibody–drug conjugates (ADCs) are designed to selectively deliver potent cytotoxic drugs within cancer cells expressing the target surface antigen. ADCs are composed of one or more cytotoxic agents connected to a mAb by a covalent bond.

FRα x NaPi2b Bispecific ADC Library Screen Design •Proof of concept system with tentative aim of targeting tumors that express either FRα, NaPi2b, or both targets (OVCA/NSCLC )

In this review, we comprehensively reviewed the current development and the prospects of ADC, provided an analysis of marketed ADCs and the ongoing pipelines globally as well as in China, highlighted several ADC platforms and technologies specific to different pharmaceutical enterprises and biotech companies, and also discussed the new related ...

We describe here a new class of PBD mono-alkylator hybrids (referred to as I-BiPs) and demonstrate their use as ADC payloads. A series of biaryl heterocyclic DNA binders were linked to a PBD monomer and the cytotoxic activities of the resulting molecules were evaluated in a panel of solid tumor cell lines.

2025年1月23日 · Bispecific ADC (antibody-drug conjugate) technology is revolutionizing targeted cancer therapy by combining the precision of bispecific antibodies with the potency of cytotoxic drugs. Unlike traditional ADCs, bispecific ADCs can simultaneously target two different antigens, enhancing tumor selectivity and reducing off-target effects.

1.应用交付网络：Application Delivery Networking（简称ADN）指利用相应的网络优化/加速设备，确认用户的业务应用能够快速、安全、可靠地交付给内内部员工和外部客户群。 关于应用交付网络的理解，可以看成将企业的关键应用交付到网络上，也就是通过利用L4到L7对基于网络的应用数据进行分析、导向，负载，加速和加密以及应用健康检查--这些”应用交换“技术将关键应用与基础设施关联起来。 3.应用发布流程过程. 《1》服务器整合：通过使用本地负载均衡（LTM）、应 …

2021年12月12日 · Here, we have prepared a protein kinase‐focused library by chemically modifying helix‐loop‐helix (HLH) peptides displayed on phage and subsequently tethered to adenosine. The library was screened against aurora kinase A (AurA). The selected HLH peptide Bip ‐ 3 retained the α‐helical structure and bound to AurA with a K D value of 13.7 μM.

Here, we have prepared a protein kinase-focused library by chemically modify-ing helix-loop-helix (HLH) peptides displayed on phage and subsequently tethered to adenosine. The library was screened against aurora kinase A (AurA). The selected HLH peptide Bip-3. retained the α-helical structure and bound to AurA with a KD value of 13.7 μM.

2021年12月10日 · Here, we have prepared a protein kinase-focused library by chemically modifying helix-loop-helix (HLH) peptides displayed on phage and subsequently tethered to adenosine. The library was screened against aurora kinase A (AurA). The selected HLH peptide Bip-3 retained the α-helical structure and bound to AurA with a K D value of 13.7 μM.