The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na +). It is …

The ubiquitin ligase Nedd4-2 normally binds tightly to ENaC by a well defined protein–protein interaction. Unphosphorylated Nedd4-2 is shown to have a higher affinity for ENaC, leading to …

2016年7月25日 · To reconcile the apparent conflicting roles of ADH in regulating both water and balance, we propose a unifying paradigm that defines the contribution of ENaC as a regulator …

2023年12月16日 · Epithelial sodium channel (ENaC) are integral to maintaining salt and water homeostasis in various biological tissues, including the kidney, lung, and colon. They enable …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a number of epithelial tissues. Abnormalities in ENaC function have been directly linked to several …

2012年6月4日 · The epithelial Na+ channel (ENaC) in the aldosterone-sensitive distal nephron (ASDN) is under negative-feedback regulation by the renin–angiotensin–aldosterone system in …

ENaC belongs to the ENaC/degenerin (ENaC/DEG) family of cation-selective ion channels [1,2,3] which spans a wide phylogenetic spectrum and is associated with functions related to sensing …

2021年3月5日 · Amiloride-sensitive epithelial sodium (Na+) channels (ENaC) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, colon, vasculature, and immune …

ENaC activity has been reported to be up-regulated by various hormone treatments including aldosterone, ADH, and insulin. Stimulation of ENaC channel activity by aldosterone occurs in …

2005年12月1日 · The epithelial Na+ channel (ENaC) is a pathway for Na+ transport across epithelia, including the kidney collecting duct, lung, and distal colon. ENaC is cr