The encoded protein, known as ADH1B or beta-ADH, can form homodimers and heterodimers with ADH1A and ADH1C subunits, exhibits high activity for ethanol oxidation [7] [8] and plays a major role in ethanol catabolism (oxidizing ethanol into acetaldehyde).

The ADH1B (Alcohol Dehydrogenase 1B (class I), Beta Polypeptide) gene and its best-known functional alleles, Arg48His (rs1229984, ADH1B*2) and Arg370Cys (rs2066702, ADH1B*3), have been investigated in relation to many phenotypic traits; most frequently including alcohol metabolism and alcohol drinking behaviors, but also human evolution, liver ...

2024年12月24日 · ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) is a Protein Coding gene. Diseases associated with ADH1B include Alcohol Dependence and Fetal Alcohol Syndrome. Among its related pathways are Oxidation by …

2025年2月8日 · ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis. Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate …

乙醇脱氢酶是一个有好几个成员的家族，但是其中的主力干将是 adh1b, 活性占80%以上。 欧美人群中这个酶的活性不高，但是汉族人群里面由于存在 R47H 的 遗传多样性 ，这个单位点氨基酸的变化显著提升了ADH1B的酶活性。

这种编码的蛋白质由 alpha、beta 和 gamma 亚基的几个同二聚体和异二聚体组成，对乙醇氧化表现出高活性，并在乙醇分解代谢中起主要作用。 编码 alpha、beta 和 gamma 亚基的三个基因在基因组片段中串联组织为基因簇。 已发现该基因的两个转录本变体编码不同的亚型。 [RefSeq 提供，2013 年 11 月] The protein encoded by this gene is a member of …

Alcohol dehydrogenase 1B (ADH1B) is a primate-specific enzyme which, uniquely among the ADH class 1 family, is highly expressed both in adipose tissue and liver. Its expression in adipose tissue is reduced in obesity and increased by insulin stimulation. Interference with ADH1B expression has also been reported to impair adipocyte function.

Which ADH or ALDH alleles a person carries influence his or her level of alcohol consumption and risk of alcoholism. Researchers to date primarily have studied coding variants in the ADH1B, ADH1C, and ALDH2 genes that are associated with altered kinetic properties of …

Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.

The ADH1B gene encodes the beta subunit of class I alcohol dehydrogenase (ADH) (EC 1.1.1.1), an enzyme that catalyzes the rate-limiting step for ethanol metabolism: the oxidation of alcohol to acetaldehyde.