P2Y 12 is a chemoreceptor for adenosine diphosphate (ADP) [5] [6] that belongs to the G i class of a group of G protein-coupled (GPCR) purinergic receptors. [7] This P2Y receptor family has …

ADP binds to and activates the ADP receptor P2Y 12 leading to the inhibition of adenylate cyclases, a decrease in cAMP, PI3 kinase activation, and an increase in AKT phosphorylation. …

P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as adenosine triphosphate, adenosine diphosphate, uridine triphosphate, uridine …

现阶段临床使用的抗动脉粥样硬化药物大多数为p2y 12 拮抗剂，其可与adp受体特异性结合，阻止adp诱导的血小板聚集活化，从而达发挥抗血栓作用 ；同时，有研究所表明p2y 2 受体拮抗剂 …

2005年5月1日 · On the basis of pharmacologic and genetic studies, it is now accepted that P2Y 1 is required for platelet activation by ADP, whereas P2Y 12 is important in synergizing with P2Y …

2011年2月17日 · Defects of P2Y 12 should be suspected when ADP, even at high concentrations (≥ 10μM), is unable to induce full, irreversible platelet aggregation. Tests that evaluate the …

2023年4月4日 · P2Y 12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y 12 has been used as a …

Adenosine diphosphate (ADP) receptor inhibitors are a drug class of antiplatelet agents, used in the treatment of acute coronary syndrome (ACS) or in preventive treatment for patients who …

2023年4月4日 · P2Y 12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its well-established role in platelet activation, blocking P2Y₁₂ has …

Human purinergic G protein-coupled receptor P2Y 1 (P2Y 1 R) is activated by adenosine 5′-diphosphate (ADP) to induce platelet activation and thereby serves as an important …