The aorta-gonad-mesonephros (AGM) region is an area derived from splanchnopleura mesoderm identified in embryonic humans, mice, and non-mammalian vertebrates such as birds and zebrafish. It contains the dorsal aorta, genital ridges and mesonephros and lies between the notochord and the somatic mesoderm, extending from the umbilicus to the ...

研究人员通过异种移植的功能分析，确认了人类的HSC于胚胎卡内基阶段（Carnegie stage，CS）14（妊娠后32天）最早出现在主动脉-性腺-中肾（aorta–gonad–mesonephros，AGM）区域。

2019年9月9日 · Long-term multi-lineage repopulating HSCs are detected firstly in the aorta–gonad–mesonephros (AGM) region at Carnegie stage (CS) 14 (32 days post coitus, dpc), with a frequency of less than ...

The first mouse adult-repopulating (definitive) HSCs emerge in the aorta-gonad-mesonephros (AGM) region at E10.5. Their numbers in this region increase thereafter and begin to decline at E12.5, thus pointing to the possible existence of both positive and negative regulation of emerging HSCs (reviewed in reference [100] ).

AGM（dorsal aorta-gonad-mesonephros, AGM）区是胚胎最早原位自发产生永久（definitive）造血干细胞（hematopietic stem cells, HSCs）的位点，组成AGM区的间质细胞则为永久造血提供微环境，AGM区内HSCs与具有间充质干细胞（mesenchymal stem cells, MSCs）特性的细胞在空间分布上密切相关 ...

2006年2月14日 · The AGM region is the first intra-embryonic area where haematopoietic stem cells (HSCs) capable of colonizing adult bone marrow have been detected . The HSCs in the AGM region divide more rapidly than those in the extra-embryonic tissue, which is consistent with an important role for the AGM in embryonic haematopoiesis.

2020年3月20日 · The involved body part and the AGM region is indicated as blue and green, respectively, with head, limb buds, heart, visceral bud, and umbilical and vitelline vessels outside the embryo proper ...

1996年9月20日 · Two sites of hematopoietic activity, the yolk sac and aorta-gonad-mesonephros (AGM) region, function in mouse ontogeny at the pre-liver stage of hematopoiesis. However, cellular interchange between these tissues obscures …

1996年9月20日 · Two sites of hematopoietic activity, the yolk sac and aorta–gonad–mesonephros (AGM) region, function in mouse ontogeny at the pre-liver stage of hematopoiesis. However, cellular interchange between these tissues obscures …

Development of hematopoietic cells in the aorta-gonad-mesonephros (AGM) region in the midgestation mouse embryo involves a multistep process, sequentially changing from endothelial cell-like cells, including hemangioblasts, into hematopoietic stem cells, progenitors, and/or lineage-committed cells.