2020年5月6日 · Desmoplakin (DSP) is a structural protein that links the cardiac desmosome to intermediate filaments and is critical for normal force transmission in the myocardium. 1 Mutations in the DSP gene encoding desmoplakin were first identified in an autosomal recessive form of arrhythmogenic cardiomyopathy. 2 Case series established DSP mutations as ...

2024年11月11日 · Introduction: Variants in the desmoplakin (DSP) gene are associated with a form of arrhythmogenic cardiomyopathy (ACM) characterized by high risk of ventricular arrhythmias (VAs), heart failure (HF), and recurrent myocarditis. The clinical implications and management of myocarditis episodes in DSP-ACM have been scarcely investigated and are a ...

2024年11月11日 · This first-in-kind population study of DSP provides insights into novel risk prediction factors, allowing us to predict pathogenicity by type and location of mutation and using variant filtering strategy to better assess phenotypic penetrance.

2005年4月18日 · Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a primary cardiomyopathy that is often diagnosed after an individual presents with arrhythmia findings. Presenting manifestations include heart palpitations, syncope, or even sudden death.

2014年1月2日 · DSP provides: (1) free training and technical assistance on best practices to pediatricians and family practice physicians to improve their identification of developmental delays and behavioral concerns; and (2) free direct support to physicians’ young patients and their families related to developmental concerns to increase linkages to early ...

J Am Coll Cardiol. 2025 Jan 13:S0735-1097 (24)10510-4. doi: 10.1016/j.jacc.2024.11.023. Online ahead of print. Keywords: ACC appropriate use criteria; cardiac resynchronization therapy; …

The American Heart Association offers three types of organizational and professional certifications to strengthen systems of care while improving patient outcomes.

2024年11月11日 · DSP cardiomyopathy is a distinct subset of arrhythmogenic cardiomyopathy, reported primarily in adults, that has predominantly left ventricular involvement and features of myocarditis. Clinical characteristics, risk stratification, and management of pediatric patients with DSP variants are not well known.

DALLAS and CHICAGO, July 27, 2020 — A new, first-of-its kind program has been developed by the American Heart Association, the world’s leading nonprofit organization focused on heart and brain health for all, in collaboration with the National Organization of Nurses with Disabilities (NOND) to meet the needs of individuals with physical ...

AHA eLearning: discover the benefits, purchase options and how to implement this innovative form of CPR, first aid, and ECC training in your organization.