Mutational analysis of the quorum-sensing receptor LasR reveals ...
Gram-negative bacteria use N-acyl L-homoserine lactone (AHL) quorum sensing (QS) signals to regulate the expression of myriad phenotypes. Non-native AHL analogs can strongly attenuate …
Quorum-sensing synthase mutations re-calibrate autoinducer ...
2023年12月2日 · Using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry, we discover that strains lacking lasR overproduce the RhlI …
综述 | 华中农大：革兰氏阴性菌群体感应信号分子对宿主细胞的影 …
2022年8月27日 · LasI/RhlI指导LuxI合成AHLs，当AHLs积累到阈值浓度时，AHLs在细菌膜外自由扩散，并与其受体LuxR结合。 LuxR-AHLs复合物激活靶基因的表达，触发毒素、生物膜、抗 …
The role of LasR active site amino acids in the interaction with the ...
2019年1月1日 · Theoretical and structural analysis of the active site of the transcriptional regulators LasR and TraR, using molecular docking methodology for identifying potential …
<i> 铜绿假单胞菌 </i>细菌群体感应机制中LasR ... - X-MOL
2009年5月17日 · 可以从在AHL缺陷培养基中生长的细胞中获得一些可溶性LasR蛋白，但它们对启动子序列OP1（ lasB 弹性蛋白酶启动子）没有结合亲和力 。 此外，活性LasR可能以LasR …
Alginate Oligosaccharide-Induced Modification of the lasI-lasR …
2018年4月26日 · The LasR–3-oxo-C 12-AHL complex activates the transcription of target genes, including those encoding virulence factors such as elastase, proteases, and exotoxin. In …
Characterization of lasR-deficient clinical isolates of Pseudomonas ...
2018年9月6日 · Three major QS systems are hierarchically arranged in P. aeruginosa 12, 13, 14, 15. At the top of the signaling cascade is the acyl-homoserine lactone (AHL)-based las system …
铜绿假单胞菌 LasR 和 RhlR 受体群体感应介导的 N-酰基高丝氨酸内酯 (AHL…
N-酰基-高丝氨酸-内酯 (AHL) 是最常见的自诱导剂，负责调节 QS 介导的毒力基因表达。铜绿假单胞菌有四个QS系统，其中LasI/R和RhlI/R系统受3-oxo-C 12-HSL和C 4调控-分别是HSL。它们 …
Characterization of LasR protein involved in bacterial quorum …
2009年5月17日 · In recombinant Escherichia coli BL21, LasR was produced as functionally-active proteins when the cells were cultivated in the presence of a proper signaling molecule (acyl …
Part:BBa C0179 - parts.igem.org
We improved this part by characterising the crosstalk between LasR and non-cognate AHLs. We found the activation range of LasR when induced with C12-AHL. For the crosstalk …