The removal of ALDH1A1 in mice through genetic knockout results in viable animals that are fertile and healthy. The only validated phenotype of these mice is a resistance to high fat diet …

2024年12月24日 · ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) is a Protein Coding gene. Diseases associated with ALDH1A1 include Alcohol Dependence and Anaerobic …

2021年12月26日 · 针对aldh1a1发挥促进乳腺癌的具体机制，他们设计了一种联合治疗策略以更高效的靶向治疗恶性乳腺癌。他们使用可以清除mdscs的化疗药物吉西他滨和 ...

2025年3月4日 · Title: The Molecular Context of Oxidant Stress Response in Cancer Establishes ALDH1A1 as a Critical Target: What This Means for Acute Myeloid Leukemia. The Prognostic …

2024年10月1日 · 研究者通过RNA-seq等发现并验证：KRAS G12C抑制剂 （Sotorasib和Adagrasib） 处理后的细胞系中，ALDH1A1基因表达及酶活性显著上调。 基因敲除和过表达 …

Aldehyde Dehydrogenase-1A1 (ALDH1A1) and Chemoresistance. ALDH1A1 is also considered a highly conserved homo-tetramer (∼55 kDa monomer), with the retina being its preferred …

2021年1月1日 · ALDH1A1 is widely expressed in varieties of human organs and tissues, such as brain, liver, kidneys, adipose, eyelens, retina, and so forth. A key role that ALDH1A1 exhibits is …

醛脱氢酶 1 家族成员 A1： 该基因编码的蛋白质属于醛脱氢酶家族。醛脱氢酶是酒精代谢主要途径中继醇脱氢酶之后的下一个酶。肝脏中有两种主要的醛脱氢酶同工酶，胞质和线粒体，它们由 …

2022年6月22日 · ALDH1A1 expression is regulated by several epigenetic processes. ALDH1A1 also acted as a tumor suppressor in certain cancers. The detoxification of ALDH1A1 often …

2016年3月8日 · In cancer therapy, ALDH1A1 provides a useful therapeutic CSC target in tissue types that normally do not express high levels of ALDH1A1, including breast, lung, esophagus, …