
ACVRL1 - Wikipedia
ACVRL1 is a receptor in the TGF beta signaling pathway. It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands.
ALK1 signaling in development and disease: new paradigms
In this review, we present an updated view of the mechanism of ALK1 signaling, put forth a unified hypothesis to explain the cellular missteps that lead to AVMs associated with ALK1 deficiency, and discuss emerging roles for ALK1 signaling in diseases beyond HHT.
ALK1 as an emerging target for antiangiogenic therapy of cancer
2011年6月30日 · Activin receptor-like kinase 1 (ALK1) is an EC-restricted receptor of the large TGF-β family. 1 Herein, we will review our current understanding of ALK1 signaling and the potential of ALK1 to serve as a drug target for antiangiogenic therapy for cancer.
ALK1 as an emerging target for antiangiogenic therapy of cancer
Activin receptor-like kinase 1 (ALK1) is an EC-restricted receptor of the large TGF-β family. 1 Herein, we will review our current understanding of ALK1 signaling and the potential of ALK1 to serve as a drug target for antiangiogenic therapy for cancer.
Molecular basis of ALK1-mediated signalling by BMP9/BMP10 …
2020年4月1日 · Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in...
ALK Gene - GeneCards | ALK Protein | ALK Antibody
2024年12月24日 · ALK (ALK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include Neuroblastoma 3 and Neuroblastoma. Among its related pathways are ASP-3026-resistant ALK mutants and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity.
Activin receptor-like kinase (ALK)1 is an antagonistic ... - PubMed
Activin receptor-like kinase-1 (ALK1) induces Smad1/5 phosphorylation, leading to an increase in endothelial cell proliferation and migration, while ALK5 promotes Smad2/3 activation and inhibits both processes.
Role of activin receptor-like kinase 1 in vascular development and ...
Activin receptor-like kinase 1 (ALK1) is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta (TGFβ) receptor superfamily. ALK1 is specifically expressed in vascular endothelial cells, and its dynamic changes are ...
Targeting ALK1 to block LDL transcytosis and halt atherosclerosis
2023年6月2日 · Genetic deletion of, or selective monoclonal antibody binding to, activin receptor-like kinase 1 (ALK1) inhibits LDL transcytosis into the endothelium and prevents the development of...
ALK1 as an emerging target for antiangiogenic therapy of cancer
2011年6月30日 · Pharmacologic inhibitors of ALK1 have recently been developed and will allow for more accurate studies of ALK1 function in vivo, as well as for assessment of ALK1 as a target for suppression of angiogenesis during tumor development.