ACVRL1 is a receptor in the TGF beta signaling pathway. It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands.

In this review, we present an updated view of the mechanism of ALK1 signaling, put forth a unified hypothesis to explain the cellular missteps that lead to AVMs associated with ALK1 deficiency, and discuss emerging roles for ALK1 signaling in diseases beyond HHT.

2011年6月30日 · Activin receptor-like kinase 1 (ALK1) is an EC-restricted receptor of the large TGF-β family. 1 Herein, we will review our current understanding of ALK1 signaling and the potential of ALK1 to serve as a drug target for antiangiogenic therapy for cancer.

Activin receptor-like kinase 1 (ALK1) is an EC-restricted receptor of the large TGF-β family. 1 Herein, we will review our current understanding of ALK1 signaling and the potential of ALK1 to serve as a drug target for antiangiogenic therapy for cancer.

2020年4月1日 · Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in...

2024年12月24日 · ALK (ALK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include Neuroblastoma 3 and Neuroblastoma. Among its related pathways are ASP-3026-resistant ALK mutants and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity.

Activin receptor-like kinase-1 (ALK1) induces Smad1/5 phosphorylation, leading to an increase in endothelial cell proliferation and migration, while ALK5 promotes Smad2/3 activation and inhibits both processes.

Activin receptor-like kinase 1 (ALK1) is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta (TGFβ) receptor superfamily. ALK1 is specifically expressed in vascular endothelial cells, and its dynamic changes are ...

2023年6月2日 · Genetic deletion of, or selective monoclonal antibody binding to, activin receptor-like kinase 1 (ALK1) inhibits LDL transcytosis into the endothelium and prevents the development of...

2011年6月30日 · Pharmacologic inhibitors of ALK1 have recently been developed and will allow for more accurate studies of ALK1 function in vivo, as well as for assessment of ALK1 as a target for suppression of angiogenesis during tumor development.