Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; it is also known as ALK-2 (a ctivin receptor- l ike k inase-2). [5] . ACVR1 has been linked to the …

ALK2（激活素受体样激酶2）由 ACVR1 基因编码，是一种骨形态发生蛋白 (BMP) I 型受体亚型，在骨骼、肌肉、大脑和其他器官的发育中起着重要的生理作用。 由于 BMP 信号传导异常激 …

This review covers the structural features of ALK2 inhibitors which contribute to their ALK2 potency and selectivity, and the pharmacokinetic or in vivo efficacy data available to …

激活素受体样激酶 2 (alk2)，也称为激活素 a 受体 1 型 (acvr1)，是转化生长因子-β 家族成员的跨膜激酶受体。野生型 alk2/acvr1 响应配体结合转导成骨信号。

Activin receptor-like kinase-2 (ALK2), encoded by the ACVR1 gene, is a bone morphogenetic protein (BMP) type-I receptor subtype that plays an important physiological role in the …

2021年8月16日 · Here, using hydrogen deuterium exchange mass spectrometry (HDX-MS), small angle X-ray scattering (SAXS) and molecular dynamics (MD) simulations, combined with …

2024年5月29日 · Gain-of-function variants in the gene encoding the activin receptor–like kinase 2 (ALK2) protein cause the disorder. Davis et al. screened a library of small-molecule kinase …

2024年11月19日 · Using DNA-encoded chemistry technology, we screened 3.94 billion unique compounds from our diverse DNA-encoded chemical libraries (DECLs) against the kinase …

2025年3月7日 · ALK genetic alterations drive various malignancies through aberrant tyrosine kinase activation, promoting oncogenic cell growth and survival. Here, Voena et al. outline …

ALK2 R206H thus represents an ideal therapeutic target for a highly selective small molecule kinase inhibitor as a treatment for FOP. We previously described the identification of a small …