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MCE-生物活性分子大师
https://www.medchemexpress.cn › proteins
激活素受体 IB (ALK-4/Activin RIB) | 重组蛋白 | MCE
alk4 是脊椎动物发育的重要调节因子，在中胚层诱导、原条形成、原肠胚形成、背前模式和左右轴确定中发挥作用。来自不同物种的 alk4 (acvr1b) 蛋白的氨基酸序列非常稳定，由此得出结 …
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ACVR1B - Wikipedia
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• Welt CK (2002). "The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction". Curr. Opin. Obstet. Gynecol. 14 (3): 317–23. doi:10.1097/00001703-200206000-00012. PMID 12032389. S2CID 44327401.
• Liu F, Ventura F, Doody J, Massagué J (1995). "Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs". Mol. Cell. Biol. 15 (7): 3479–86. doi:10.1128/mcb.15.7.3479. PMC
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• Welt CK (2002). "The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction". Curr. Opin. Obstet. Gynecol. 14 (3): 317–23. doi:10.1097/00001703-200206000-00012. PMID 12032389. S2CID 44327401.
• Liu F, Ventura F, Doody J, Massagué J (1995). "Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs". Mol. Cell. Biol. 15 (7): 3479–86. doi:10.1128/mcb.15.7.3479. PMC 230584.
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知乎专栏
https://zhuanlan.zhihu.com
肿瘤免疫潜力靶点 “TGF-β通路及其全球新药开发” 进展迅速 - 知乎
使 Smad2 和 Smad3 磷酸化的主要是TGF-β亚家族（ALK4，ALK5和ALK7）的I型受体（PS：基于ALK5的抑制剂开发较多），而Smad3对诱导HSCs活化和促纤维化基因转录至关重要。 …
GeneCards
https://www.genecards.org › cgi-bin › carddi…
ACVR1B Gene - GeneCards | ACV1B Protein | ACV1B …
2024年12月24日 · ACVR1B (Activin A Receptor Type 1B) is a Protein Coding gene. Diseases associated with ACVR1B include Pancreatic Cancer and Transposition Of The Great Arteries, Dextro-Looped.Among its related …
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Principles of the activin receptor signaling pathway and its inhibition
2021年8月1日 · ALK4, ALK5, or ALK7 antagonism pivots around small-molecule inhibitors. The small-molecule inhibitors work by occupying the adenosine triphosphate binding site of the …
- 作者: Andreas Lodberg
- Publish Year: 2021

Nature
https://www.nature.com › articles
ALK4/5-dependent TGF-β signaling contributes to the …
2019年5月3日 · The present results show that neurons and microglia both use ALK4/5 (a type of TGF-β receptor) signaling in order to maintain mutual exchanges in an adult brain following an axonal injury.
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What does ALK4 stand for?
New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration. Keywords: Duchenne muscular dystrophy; antisense oligonucleotides; muscle mass; muscle metabolism; myostatin/activin pathway. © The Author (s).
New function of the myostatin/activin type I receptor (ALK4) as a media…
pubmed.ncbi.nlm.nih.gov
What is ALK5 & ALK4 kinase toxicity?
ALK4, ALK5, or ALK7 antagonism pivots around small-molecule inhibitors. The small-molecule inhibitors work by occupying the adenosine triphosphate binding site of the ALK kinase, thereby obstructing its phosphorylation of Smad2/3 . ALK5 inhibitors have a propensity for cardiovascular toxicity that has not been reported with other IASPs .
Principles of the activin receptor signaling pathway and its inhibition
sciencedirect.com
What is the molecular characterization of alk4/5?
Molecular characterization of ALK4/5: a TGF-β family type I receptor (TGF-β R1). (a) Nucleotide and amino acid sequences of leech ALK4/5. The numbers of nucleotides are indicated in left and of amino acids in right. The five disulfide bridges are highlighted in dark grey.
ALK4/5-dependent TGF-β signaling contributes to the crosstalk ... - Nat…
nature.com
Is ALK4 a member of the TGF- family?
The leech ALK4/5 possesses amino acid residues belonging to the TGF-β family type I receptor 28, 29, 31, 32. The present report showed the use of the ALK4/5 pathway in the microglia recruitment and the existence of a member of the TGF-β family similar to GDF8 (alias myostatin) and GDF11 both recognizing ALK4 or ALK5 40, 41.
ALK4/5-dependent TGF-β signaling contributes to the crosstalk ... - Nat…
nature.com
What does ALK stand for?
ALK (ALK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include Neuroblastoma 3 and Neuroblastoma. Among its related pathways are ASP-3026-resistant ALK mutants and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity.
ALK Gene - GeneCards | ALK Protein | ALK Antibody
genecards.org
How important is alk4/5 signaling in axon regeneration?
The results demonstrate that ALK4/5 signaling is essential throughout the response to the lesion in the crosstalk between microglia and neurons. They may give a new insight into the functions of this pathway as an important signal contributing to a correct sequential mobilization of microglia leading to an axon regeneration.
ALK4/5-dependent TGF-β signaling contributes to the crosstalk ... - Nat…
nature.com
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知乎专栏
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ALK基因的突变与靶向治疗 - 知乎 - 知乎专栏
PTKs的异常激活是肿瘤发生的重要机制之一。ALK（anaplastic lymphoma kinase，间变性淋巴瘤激酶）属于受体型PTKs家族，主要在神经系统表达，是目前研究相对较多的一种PTKs，它与多种肿瘤的发生有着密切的联系。本…
知乎专栏
https://zhuanlan.zhihu.com
靶向 TGF-β 信号通路 | MedChemExpress - 知乎 - 知乎 …
Vactosertib 还以纳摩尔浓度抑制 ALK2 和 ALK4 (IC50 为 17.3 nM)，具有强大的抗转移活性和抗癌作用。 GW788388 有效的 ALK5 抑制剂，IC50 值 18 nM。
GeneCards
https://www.genecards.org › cgi-bin › carddi…
ALK Gene - GeneCards | ALK Protein | ALK Antibody
2024年12月24日 · Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the …
PubMed
https://pubmed.ncbi.nlm.nih.gov
New function of the myostatin/activin type I receptor (ALK4) as a ...
Antisense oligonucleotides (AONs) were designed specifically to block the function of ALK4, a key receptor for the MSTN/activin pathway in skeletal muscle. AON-induced exon skipping …
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