2021年8月10日 · Frontotemporal degeneration or frontotemporal dementia (FTD) refers to a group of disorders that causes progressive damage to the temporal and frontal lobes of the brain associated with personality, behavior and language. Loss of function in this area of the brain can lead to impulsive behavior and speech difficulties.

2025年3月14日 · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration is the official journal of the World Federation of Neurology Research Group on Motor Neuron Diseases. It enhances awareness and disseminates information on new developments in the pathogenesis and management of ALS and FTD.

In 2011, researchers identified a variant in the C9orf72 gene as the most common cause of both genetic FTD and genetic amyotrophic lateral sclerosis (ALS). Previously, ALS was thought to be purely a movement disorder, while FTD was considered purely a cognitive or …

This article presents the revised consensus criteria for the diagnosis of frontotemporal dysfunction in amyotrophic lateral sclerosis (ALS) based on an international research workshop on frontotemporal dementia (FTD) and ALS held in London, Canada in June 2015.

2013年8月7日 · Breakthrough discoveries identifying common genetic causes for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these disorders. They share unexpectedly similar signatures, including dysregulation in common molecular players including TDP-43, FUS/TLS …

In contrast with ALS-ci/bi cases, when patients with ALS had co-occurrent dementia (ALS-FTD), our study has outlined not only a pattern of microstructural damage involving motor networks (i.e., the characteristic ALS-cn-like pattern), but also a disruption of frontal, temporal, parietal, and striatal circuits, both from a structural and a ...

There is increasing recognition of a clinical overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Recent advances in our understanding of the neuropathologic, biochemical, and genetic basis of these conditions provides evidence for a common underlying pathogenesis. …

6 天之前 · The ALS-FTD disease spectrum. Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are both fatal and progressive adult-onset neurodegenerative diseases [Citation 1, Citation 2].The genetic, clinical and neuropathological overlap of ALS and FTD is in line with anALS/FTD disease spectrum with pure ALS and FTD at the extremes, and intermediate phenotypes distributed throughout ...

1 天前 · Background Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share overlapping clinical, genetic, and neuroimaging features; a spectrum of conditions commonly referred to as the ALS-FTD continuum. The majority of imaging studies focus on supratentorial pathology, and phenotype-defining motor, cognitive, and behavioural profiles are often exclusively attributed to ...

2018年8月17日 · In this article, we review the pathological and mechanistic features of C9orf72 -associated FTD and ALS (collectively termed C9FTD/ALS), the model systems used to study these conditions, and...