Detection of serine 473 phosphorylated Akt in acute myeloid
The phosphoinositide 3-kinase/Akt signalling pathway is a recently recognized important parameter in the prognosis and the response to treatment of acute myeloid leukaemia (AML). Akt kinase is activated by phosphorylation on Thr 308 and Ser 473. Active Akt promotes cell growth and survival to apopto …
Detection of serine 473 phosphorylated Akt in acute myeloid …
2004年7月30日 · Akt kinase is activated by phosphorylation on Thr 308 and Ser 473. Active Akt promotes cell growth and survival to apoptotic insults. Thus, it seems important to evaluate Akt phosphorylation in AML blasts. This work aimed to establish whether it was possible to detect Akt phosphorylation on Ser 473 of AML blasts by means of flow cytometry.
The level of AKT phosphorylation on threonine 308 but not on serine 473 ...
2009年1月22日 · As full activation of Akt requires phosphorylation on both threonine 308 (Thr308) and serine 473 (Ser473) residues, we studied the level of phosphorylation on the both sites in 58 AML samples...
The Level of AKT Phosphorylation on Threonine 308 but Not on Serine 473 ...
2008年11月16日 · This study shows that AML cells with complex karyotype display high level of phosphorylation of AktThr308 and suggests that this anti-apoptotic pathway may represent a valuable therapeutic target. Thus, it will be important to determine in clinical trials if this aberrant activation of Akt sensitizes AML cells to PI3K/Akt inhibitors ...
Optimizing venetoclax dose in combination with low intensive
The objective of this research was to characterize the venetoclax exposure-efficacy and exposure-safety relationships and determine its optimal dose in elderly patients with newly diagnosed acute myeloid leukemia (AML) receiving venetoclax in combination with low intensity therapies (hypomethylating …
Detection of serine 473 phosphorylated Akt in acute
2004年10月1日 · Akt kinase is activated by phosphorylation on Thr 308 and Ser 473. Active Akt promotes cell growth and survival to apoptotic insults. Thus, it seems important to evaluate Akt phosphorylation in...
The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target …
2012年2月16日 · AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases. Critical role for PI 3-kinase in the control of …
正常核型急性髓系白血病预后分析 - PMC - PubMed Central (PMC)
急性髓系白血病(aml)是一种基因型、表型、临床特征及预后都表现出异质性的疾病。 目前，核型是评估AML预后的重要指标。 采用传统的染色体条带分析方法，40%～49％的患者表现为正常核型(CN-AML) [1] ，这部分患者在预后方面仍然表现出异质性。
(PDF) Detection of serine 473 phosphorylated Akt in acute …
Acute myeloid leukaemia (AML) is a disease characterized by the accumulation of immature myeloid cells in the bone marrow and the suppression of normal haematopoiesis. Leukaemic blast cells display a myriad of genetic abnormalities, including
Activation of Akt in primary human AML. Tissue array
Expression levels of p-Ser 473 -Akt were analyzed by immunohistochemistry, as shown for a bone marrow biopsy of an individual patient. B, examples of membrane/cytosol staining (left) and nuclear...