2022年11月15日 · Introduction: Acute myeloid leukemia (AML) with complex karyotype (CK), which is defined as ≧3 chromosome abnormalities, has a poor prognosis. In a few reports, CK-AML was classified into typical CK-AML and atypical CK-AML (Mrózek, et al. Leukemia 2019; Leung, et al. Am J Hematol 2019; Schoch, et al. Genes Chromosomes Cancer 2005).

2023年5月8日 · At the DNA level (Fig. 1A, somatic mutation and DNA copy number), the iSubtype 1 was characterized by complex karyotypes (CK) and high-frequency mutation of TP53 (30%) and RUNX1 (27%); the...

Complex karyotype (CK) with ≥3 abnormalities is detected in 10-12% of patients with acute myeloid leukemia (AML) and associated with poor prognosis. The most common unbalanced abnormalities found in CK result in loss of material from the 5q, 7q and/or 17p chromosome arms.

2024年12月5日 · 急性髓系白血病（Acute Myeloid Leukemia, AML）是一种侵袭性血液恶性肿瘤，其中复杂核型（Complex Karyotype, CK-AML）约占所有AML病例的10-12%，是预后较差的亚型之一。 CK-AML的显著特征是其复杂的染色体异常（通常有三种或以上），导致高度的基因组不稳定性（Genomic Instability），从而引发了显著的肿瘤内部异质性（Intratumoral Heterogeneity, ITH）。 这种异质性使得标准治疗对该亚型的疗效显著降低，导致预后极差。

复杂核型（CK）是AML患者独立的不良预后因素，近年研究证实单体核型（MK）作为一类新的细胞遗传学异常，比CK更能提示AML患者预后不良 [1, 2, 3]。 我们通过回顾性分析498例成人AML患者资料，旨在探索MK在AML患者中的预后意义。 2001年7月至2013年7月我院收治的经重新评估符合2008年WHO诊断标准 [4] 且具有可供分析的染色体核型结果的498例成人AML患者（急性早幼粒细胞白血病除外）。 患者骨髓细胞经24~ 48 h培养后，收集细胞常规制片，R或G显带，染色 …

2024年11月27日 · We harnessed two single-cell multiomics methods to characterize the heterogeneity of acute myeloid leukemia with complex karyotype (CK-AML). Our data link genetic, non-genetic and functional...

2023年10月27日 · Acute myeloid leukemia with complex karyotype (CK-AML) is associated with poor prognosis, which is only in part explained by underlying TP53 mutations. Especially in the presence of complex chromosomal rearrangements, such as chromothripsis, the outcome of …

Complex karyotype (CK) with ≥ 3 abnormalities is detected in 10-12% of patients with acute myeloid leukemia (AML) and associated with poor prognosis. The most common unbalanced abnormalities found in CK result in loss of material from the 5q, 7q, and/or 17p chromosome arms.

Complex karyotype acute myeloid leukemia (CK-AML) has a dismal outcome with current treatments, underscoring the need for new therapies. Here, we report synergistic anti-leukemic activity of the BCL-2 inhibitor venetoclax (Ven) and the asparaginase formulation Pegylated Crisantaspase (PegC) in CK-AM …

2024年11月26日 · 新研究利用单细胞多组学技术揭示了复杂核型急性髓系白血病（ck-aml）的克隆演化过程，并发现可被靶向的治疗窗口，为开发精准治疗手段提供了新视角，有望克服治疗耐药性和降低复发风险。