2024年7月18日 · Extramedullary deposits of acute myeloid leukemia (eAML), constitute an unusual presentation or complication of AML, which can occur in isolation (isolated eAML) or in the context...

2024年11月5日 · Here, we aim to analyze pts with MDS/AML overlap to highlight differences in molecular features and clinical outcomes using MDS-based IPSS-M and AML-based ELN risk stratifications. Also, we identified distinct molecular signatures of MDS/AML cases based on our previously reported machine learning unsupervised molecular clustering approach ...

2021年11月5日 · Myelodysplastic syndrome (MDS) has been associated with co-occurring ailments of various origin. In particular, rheumatologic disorders (Felty's syndrome, VEXAS), malignancies such as LGL (large granular lymphocytosis) and pre-malignant conditions like MGUS (monoclonal gammopathy of undetermined significance) are among the most frequent.

2023年8月26日 · When these 12 genes were analyzed in one sample with AML carrying -7, we identified a small population of likely wild-type cells characterized by high mRNA expression levels of MDFIC, PILRA and...

2024年5月11日 · Trisomy 6 has been observed in myelodysplastic neoplasm (MDS) and acute myeloid leukemia (AML) and can occur as a sole genomic abnormality. It has also been reported in AA and other bone...

2024年7月25日 · 急性髓系白血病的髓外沉积 (eAML)是 AML 的一种罕见表现或并发症，可单独发生（孤立性eAML）或在诊断或复发时发生完全白血病过程（同步eAML）。 AML 的这种特殊和罕见变体可能是由于独特生物学特征促进原始细胞归巢至非造血部位或/和特定分子病变的结果，可能与恒定（invariant）基因型有关。 尽管近十年来分子研究和二代测序取得了进展，但对该现象的系统研究却很少。 此外，虽然在2022年WHO) 分类中得到认可，但ELN 2022 AML 指南中未纳 …

We have collected clinical and molecular data of 7400 patients with myeloid neoplasms and applied a novel model by identifying an optimal VAF cutoff using a statistically robust strategy of sampling-based regression on survival data to accurately classify the TP53 allelic configuration and assess prognosis more precisely.

2022年10月9日 · AML分级框架指导临床前药物研究. 为了了解药物治疗如何影响细胞组成，作者从Gene Expression Omnibus（GEO）和ArrayExpress的43个数据集中提取RNA-seq数据，对药物治疗前后测序的人类AML细胞进行反卷积（图5a，b）。

2024年12月5日 · 急性髓系 白血病 （Acute Myeloid Leukemia, AML）是一种严重威胁生命的血液系统 恶性肿瘤，尤其是复杂核型 急性髓系白血病 （Complex Karyotype AML, CK-AML）更是众多亚型中预后较差的一种。 CK-AML的患者通常面临着复杂的染色体重排和明显的基因组不稳定性，这使得他们对传统治疗方法的反应不佳，生存率低。 面对如此严峻的挑战，研究人员正在探索更深层次的细胞和基因组层面的机制，以寻找突破性的治疗策略。

Background: While NPM1-mutated AML in the absence of FLT3-ITD generally carries a favorable prognosis, large registry studies suggest the positive prognostic benefit may not extend to patients > 65 years of age. We examined this preferential, age-dependent prognostic impact through a real-world analysis of 2811 adult AML patients. Results: …

2024年7月30日 · FLT3MT occurs in about 30% of acute myeloid leukemia (AML) cases, with internal tandem duplications (ITD; FLT3ITD) accounting for 80% of all FLT3MT cases. In addition to FLT3ITD, distinct point...

2023年11月2日 · DNMT3A mutations are present in approximately 20% of acute myeloid leukemia (AML) patients and other myeloid neoplasms (MN) and are considered the earliest clonal event in leukemogenesis. In AML, 50-60% of DNMT3A mutations are heterozygous missense mutations affecting codon R882, which were shown to …

Low-risk MDS (LR-MDS), high-risk MDS (HR-MDS), sAML, and primary AML (pAML) were present in 34%, 17%, 4%, and 27%, respectively (Table 1 and Figure S1). For this study, HR-MDS patients were defined by a blast count of ≥ 5%.

2024年12月2日 · The search query included various subtypes of leukemia such as AML, myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia, chronic myeloid leukemia (CML), and chronic lymphocytic leukemia (CLL), as well as related terms such as blast crisis and myelodysplasia, and the details were provided in Appendix 1.

aml是成人最常见、最致命的一种急性白血病，临床常用的治疗手段为化疗、靶向治疗和造血干细胞移植等。本次指南更新对不同治疗阶段aml进行了多种方案的新增和调整，进一步促进aml的治疗趋于规范化和精准化，有望攻克aml治疗困境。 参考文献：

2025年2月12日 · Disease overview: Acute myeloid leukemia (AML) is a bone marrow stem cell cancer that is often fatal despite available treatments. Diagnosis, risk assessment, monitoring, and therapeutic management of AML have changed dramatically in the last decade due to increased pathophysiologic understanding, improved assessment technology, and the ...

2023年8月9日 · Myelodysplastic syndromes (MDS) have varied prognoses and require a risk-adapted treatment strategy for treatment optimization. Recently, a molecular prognostic model (Molecular International...

2024年11月19日 · Acute myeloid leukemia (AML) encompasses a diverse range of myeloid malignancies. While the prognosis for de novo AML in young patients is relatively favorable, with a 40% to 50% long-term survival rate, the outcomes for older individuals with secondary or refractory/relapsed (R/R) AML are markedly inferior with long-term survival rates of ...

2022年8月8日 · Clinical recommendations for Acute Myeloid Leukemia (AML) classification and risk-stratification remain heavily reliant on cytogenetic findings at diagnosis, which are present in <50% of...

2025年3月10日 · 1.展示了mdm2p53（PROTAC）+V药的联合在AML上有着近乎完美的模型，且比KT253单药好太多太多。 2.KT253在ASCO2024发布的一期数据，单药看到了一些疗效，同时有着几乎无可挑剔的安全性数据，几乎没有骨髓抑制，拥有着极其广阔的联合治疗窗口。 3.相对于APG115和KT253单药疗效不足的问题，以及相比APG115骨髓抑制的问题，与bcl2的联合，合成致死机制，随着BCL2剂量推上去，实现了近乎完美（近乎两个字都可以去掉）的模型。