Choosing the appropriate cell line for acute myeloid leukemia (AML) research is crucial for obtaining reliable and relevant results. Several factors should be considered when selecting a cell line for AML research, such as specific markers and genetic abnormalities associated with different subtypes of AML.

A panel of 7 leukemia cell lines representing Acute Myeloid Leukemia (AML), Acute Monocytic Leukemia (AMoL), Chronic Myeloid Leukemia (CML), and Acute Lymphoblastic Leukemia (ALL). Each culture contains genomic mutations in one or more of the following genes according to the Sanger COSMIC database: CDKN2A, KDM6A, TP53, NRAS, NOTCH1, PTEN, FBXW7 ...

Several human acute myeloid leukemia cell lines were recently established. These lines provide model systems to study the control of differentiation in human myelogenous leukemia and, in a broader framework, the controls of normal myeloid development.

2023年3月11日 · Choosing the appropriate cell line for acute myeloid leukemia (AML) research is crucial for obtaining reliable and relevant results. Several factors should be considered when selecting a cell line for AML research, such as specific markers and genetic abnormalities associated with different subtypes of AML.

2023年1月12日 · Here, we define the mutational landscape of 76 AML cell lines by targeted sequencing, and integrate this information with available karyotyping data to generate a single comprehensive resource of...

Origins and properties of hematopoietic growth factor-dependent cell lines. Two-step differentiation of AML-193 leukemic line: terminal maturation is induced by positive interaction of retinoic acid with granulocyte colony-stimulating factor (CSF) and vitamin D3 with monocyte CSF. Human factor-dependent leukemia cell lines.

2025年2月1日 · We established a novel AML cell line, YCU-AML2, and its xenograft model harboring KMT2A::MLLT3 rearrangement, MECOM overexpression, and KRAS G12A mutation. YCU-AML2 xenograft mice models developed AML …

Acute myeloid leukemia (AML) is the most common acute leukemia in adults and is characterized by the accumulation of poorly differentiated myeloid cells. 1 With an overall 2-year survival rate of less than 50%, AML is an aggressive hematological malignancy. 2 Although 60%–80% of patients achieve complete remission after standard chemotherapy ...

Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene. J. Hematol. Oncol. 10:26.1-26.5 (2017)

Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin. JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders. Survey of activated FLT3 signaling in leukemia. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.